ArticleRheumatology international2012
Association of toll-like receptor 9 gene polymorphism in Chinese patients with systemic lupus erythematosus in Taiwan.
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- TLR9 polymorphisms and systemic lupus erythematosus risk: an update meta-analysis study.Rheumatology international · 2016Pooled it
- Association of TLR7 and TLR9 genes polymorphisms in Egyptian patients with systemic lupus erythematosus.Heliyon · 2022Article
- Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification.Frontiers in immunology · 2021Review
- From autoinflammation to autoimmunity: old and recent findings.Clinical rheumatology · 2018Review
- Lack of Associations between TLR9 and MYD88 Gene Polymorphisms and Risk of Chronic Lymphocytic LeukemiaAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment.Frontiers in pharmacology · 2014Article
- Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer's disease in Han Chinese.Journal of neuroinflammation · 2013Article
- Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus.Rheumatology international · 2013Article
- TLR7 and TLR9 in SLE: when sensing self goes wrong.Immunologic research · 2012Review
- Integration of B cell responses through Toll-like receptors and antigen receptors.Nature reviews. Immunology · 2012Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine whether toll-like receptor 9 (TLR9) gene polymorphisms were markers of susceptibility to or severity of systemic lupus erythematosus (SLE) in Taiwanese patients. The study included 211 healthy individuals and 167 Chinese patients with SLE. Polymorphisms of TLR9 [rs2066807 and rs187084 (-1486 T/C)] were typed from genomic DNA. The genotypes, allelic frequencies, and carriage rates were compared between patients with SLE and control subjects. The relationship between allelic frequencies and clinical manifestations of 167 patients with SLE was evaluated. There was no statistically significant difference in TLR9 (rs2066807) gene polymorphism, allelic frequency, and carriage rate between the SLE and control groups. However, for the genotype of TLR9 -1486 T/C (rs187084) polymorphism, there was a statistically significant difference between the SLE and the control groups (P < 0.001, χ(2) = 15.9). Moreover, there was a significant association between the two groups in allelic frequency and carriage rate of the T allele (P < 0.001, χ(2) = 18.5 and P < 0.01, χ(2) = 8.06, respectively). We did not detect any association between the TLR9 genotype and the clinical or laboratory profiles in patients with SLE. The results suggest that the TLR9 -1486 T/C (rs187084), but not TLR9 (rs2066807), polymorphism is related to SLE in Taiwanese patients.
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