ArticleApoptosis : an international journal on programmed cell death2011
In vivo targeting of cell death using a synthetic fluorescent molecular probe.
Article in Apoptosis : an international journal on programmed cell death, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Optical and Photoacoustic Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy.Translational oncology · 2021Article
- Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.The EMBO journal · 2020Article
- Targeted photodynamic therapy treatment ofOncotarget · 2019Article
- Validation of 2-Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- Photodynamic Therapy for Metastatic Melanoma Treatment: A Review.Technology in cancer research & treatment · 2018Review
- Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes.Chemical communications (Cambridge, England) · 2016Review
- Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death.Bioconjugate chemistry · 2016Article
- Non-invasive in vivo imaging of arthritis in a collagen-induced murine model with phosphatidylserine-binding near-infrared (NIR) dye.Arthritis research & therapy · 2015Article
- Molecular imaging of apoptosis: from micro to macro.Theranostics · 2015Review
- Smart molecules for imaging, sensing and health (SMITH).Beilstein journal of organic chemistry · 2015Review
- Selective recognition of anionic cell membranes using targeted liposomes coated with zinc(ii)-bis(dipicolylamine) affinity units.Organic & biomolecular chemistry · 2014Article
- Bis(zinc-dipicolylamine), Zn-DPA, a new marker for apoptosis.Investigative ophthalmology & visual science · 2014Article
- Library synthesis, screening, and discovery of modified Zinc(II)-Bis(dipicolylamine) probe for enhanced molecular imaging of cell death.Bioconjugate chemistry · 2014Article
- A low molecular weight zinc2+-dipicolylamine-based probe detects apoptosis during tumour treatment better than an annexin V-based probe.European radiology · 2014Article
- Enhanced cell death imaging using multivalent zinc(II)-bis(dipicolylamine) fluorescent probes.Molecular pharmaceutics · 2013Article
- Effect of Bridging Anions on the Structure and Stability of Phenoxide Bridged Zinc Dipicolylamine Coordination Complexes.Supramolecular chemistry · 2013Article
- Illuminating the lipidome to advance biomedical research: peptide-based probes of membrane lipids.Future medicinal chemistry · 2013Review
- Beyond annexin V: fluorescence response of cellular membranes to apoptosis.Cytotechnology · 2013Article
- Convenient Synthesis of Multivalent Zinc(II)-Dipicolylamine Complexes for Molecular Recognition.Tetrahedron letters · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A synthetic, near-infrared, fluorescent probe, named PSS-794 was assessed for its ability to detect cell death in two animal models. The molecular probe contains a zinc(II)-dipicolylamine (Zn(2+)-DPA) affinity ligand that selectively targets exposed phosphatidylserine on the surface of dead and dying cells. The first animal model used rats that were treated with dexamethasone to induce thymic atrophy. Ex vivo fluorescence imaging and histological analysis of excised organs showed thymus uptake of PSS-794 was four times higher than a control fluorophore that lacked the Zn(2+)-DPA affinity ligand. In addition, the presence of PSS-794 produced a delayed and higher build up of dead and dying cells in the rat thymus. The second animal model employed focal beam radiation to induce cell death in tumor-bearing rats. Whole-body and ex vivo imaging showed that the amount of PSS-794 in a radiation-treated tumor was almost twice that in a non-treated tumor. The results indicate that PSS-794 may be useful for preclinical optical detection of tumor cell death due to therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.