ArticleMolecular and cellular biochemistry2011
Tetanic contractions impair sarcomeric Z-disk of atrophic soleus muscle via calpain pathway.
Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Calpain-dependent degradation of cytoskeletal proteins as a key mechanism for a reduction in intrinsic passive stiffness of unloaded rat postural muscle.Pflugers Archiv : European journal of physiology · 2022Article
- Skeletal muscle-specific calpastatin overexpression mitigates muscle weakness in aging and extends life span.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Breakdown of Filamentous Myofibrils by the UPS-Step by Step.Biomolecules · 2021Review
- Muscle-specific activation of calpain system in hindlimb unloading rats and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Human muscle signaling responses to 3-day head-out dry immersion.Journal of musculoskeletal & neuronal interactions · 2015Article
- Activity, abundance and expression of Ca²⁺-activated proteases in skeletal muscle of the aestivating frog, Cyclorana alboguttata.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- No-dependent signaling pathways in unloaded skeletal muscle.Frontiers in physiology · 2015Review
- Passive stretch reduces calpain activity through nitric oxide pathway in unloaded soleus muscles.Molecular and cellular biochemistry · 2012Article
- Various jobs of proteolytic enzymes in skeletal muscle during unloading: facts and speculations.Journal of biomedicine & biotechnology · 2012Review
- Molecular Mechanisms of Muscle Tone Impairment under Conditions of Real and Simulated Space Flight.Acta naturaeArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine whether or not over-activation of calpains during running exercise or tetanic contractions was a major factor to induce sarcomere lesions in atrophic soleus muscle. Relationship between the degrees of desmin degradation and sarcomere lesions was also elucidated. We observed ultrastructural changes in soleus muscle fibers after 4-week unloading with or without running exercise. Calpain activity and desmin degradation were measured in atrophic soleus muscles before or after repeated tetani in vitro. Calpain-1 activity was progressively increased and desmin degradation was correspondingly elevated in 1-, 2-, and 4-week of unloaded soleus muscles. Calpain-1 activity and desmin degradation had an additional increase in unloaded soleus muscles after repeated tetani in vitro. PD150606, an inhibitor of calpains, reduced calpain activity and desmin degradation during tetanic contractions in unloaded soleus muscles. The 4-week unloading decreased the width of myofibrils and Z-disk in soleus fibers. After running exercise in unloaded group, Z-disks of adjacent myofibrils were not well in register but instead were longitudinally displaced. Calpain inhibition compromised exercise-induced misalignment of the Z-disks in atrophic soleus muscle. These results suggest that tetanic contractions induce an over-activation of calpains which lead to higher degrees of desmin degradation in unloaded soleus muscle. Desmin degradation may loose connections between adjacent myofibrils, whereas running exercise results in sarcomere injury in unloaded soleus muscle.
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