ArticleStem cell reviews and reports2011
Specific unsaturated fatty acids enforce the transdifferentiation of human cancer cells toward adipocyte-like cells.
Article in Stem cell reviews and reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- PPARγ Mediates Transdifferentiation of CX3CR1International journal of molecular sciences · 2026Article
- Comparative Study of Porcine Mesenchymal Stem Cells Behavior and Lipid Metabolism on Plant-Based Scaffolds and Two-Dimensional Systems for Cultivated Fat.Engineering in life sciences · 2025Article
- Microenvironmental determinants of cancer progression during obesity: emerging evidence and novel perspectives.Journal of translational medicine · 2025Review
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- Statins Lower Lipid Synthesis But Promote Secretion of Cholesterol-Enriched Extracellular Vesicles and Particles.Frontiers in oncology · 2022Article
- Influence of olive oil and its components on mesenchymal stem cell biology.World journal of stem cells · 2019Review
- Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities.Genes & development · 2019Review
- Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia.International journal of molecular sciences · 2016Review
- Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer.Journal of Cancer · 2016Article
- Emerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approach.Journal of experimental & clinical cancer research : CR · 2013Review
- Cancer stem cells and tumor transdifferentiation: implications for novel therapeutic strategies.American journal of stem cells · 2013Article
- Ovarian cancer stem cells: a new target for cancer therapy.BioMed research international · 2013Review
- Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary.Journal of ovarian research · 2012Article
- Overcoming challenges of ovarian cancer stem cells: novel therapeutic approaches.Stem cell reviews and reports · 2012Review
- Transdifferentiation of MALME-3M and MCF-7 Cells toward Adipocyte-like Cells is Dependent on Clathrin-mediated Endocytosis.SpringerPlus · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differentiation therapy pursues the discovery of novel molecules to transform cancer progression into less aggressive phenotypes by mechanisms involving enforced cell transdifferentiation. In this study, we examined the identification of transdifferentiating adipogenic programs in human cancer cell lines (HCCLs). Our findings showed that specific unsatturated fatty acids, such as palmitoleic, oleic and linoleic acids, trigger remarkable phenotypic modifications in a large number of human cancer cell lines (HCCLs), including hepatocarcinoma HUH-7, ovarian carcinoma SK-OV-3, breast adenocarcinoma MCF-7 and melanoma MALME-3M. In particular, we characterized a massive biogenesis of lipid droplets (LDs) and up-regulation of the adipogenic master regulator, PPARG, resulting in the transdifferentiation of HCCLs into adipocyte-like cells. These findings suggest the possibility of a novel strategy in cancer differentiation therapy via switching the identity of HCCLs to an adipogenic phenotype through unsaturated fatty acid-induced transdifferentiation.
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