SynthesisRheumatology international2012
Association of TNF-α promoter-308 A/G polymorphism with susceptibility to systemic lupus erythematosus: a meta-analysis.
Synthesis in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Association between the TNF-α-308G/A and TNF-α-238G/A polymorphisms and systemic lupus erythematosus susceptibility: an updated meta-analysis.Frontiers in medicine · 2026Pooled it
- Risk factors of systemic lupus erythematosus: an overview of systematic reviews and Mendelian randomization studies.Advances in rheumatology (London, England) · 2023Review
- Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program.Rheumatology advances in practice · 2023Article
- Synergetic Interaction of HLA-DRB1*07 Allele and TNF-Alpha - 863 C/A Single Nucleotide Polymorphism in the Susceptibility to Systemic Lupus Erythematosus.Indian journal of clinical biochemistry : IJCB · 2021Article
- TNF-α - 308 G > A and IFN-γ + 874 A > T gene polymorphisms in Egyptian patients with lupus erythematosus.Meta gene · 2016Article
- Serum levels of cytokines in systemic lupus erythematosus : Association study in a Chinese population.Zeitschrift fur Rheumatologie · 2014Article
- High expression of TNF alpha is associated with -308 and -238 TNF alpha polymorphisms in knee osteoarthritis.Clinical and experimental medicine · 2014Article
- Clinical implications of shared genetics and pathogenesis in autoimmune diseases.Nature reviews. Endocrinology · 2013Review
- Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus.Clinical & developmental immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Published data on the association between tumor necrosis factor-alpha (TNF-α) promoter-308 A/G polymorphism and systemic lupus erythematosus (SLE) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 28 studies including 2,992 cases and 4,326 controls (5,924 cases and 8,484 controls in A versus G comparison) were involved in this meta-analysis. Meta-analysis was performed for genotypes A/A (recessive effect), A/A+A/G (dominant effect), and A allele in fixed or random effects models. In addition, we also performed a "model-free" analysis by considering the G/G genotype as the reference and estimated the OR for the A/A versus G/G and A/G versus G/G genotype. Overall, an association of TNF-α promoter-308 A/G polymorphism with SLE was found (A versus G: OR = 1.686, 95% CI = 1.400-2.032, P < 0.001; A/A versus A/G+G/G: OR = 3.043, 95% CI = 2.185-4.238, P < 0.001; A/A+A/G versus G/G: OR = 1.822, 95% CI = 1.379-2.407, P < 0.001; A/A versus G/G: OR = 3.686, 95% CI = 2.628-5.172, P < 0.001; A/G versus G/G: OR = 1.691, 95% CI = 1.291-2.215, P < 0.001). However, stratification by ethnicity indicated that the risk A allele was not associated with SLE in Asian (A versus G: OR = 1.207, 95% CI = 0.856-1.702, P = 0.283) and African population (A versus G: OR = 1.225, 95% CI = 0.597-2.516, P = 0.580). In summary, this meta-analysis indicated that TNF-α promoter-308-A/G polymorphism is associated with susceptibility to SLE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.