Evidence map›Paper›PMID 21499571›Full record

ArticleMolecular and cellular pharmacology2010

The Nucleolus Takes Control of Protein Trafficking Under Cellular Stress.

Narasimharao Nalabothula, Fred E Indig, France Carrier

Abstract read
In one paragraph

Article in Molecular and cellular pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  14. Synthesis and evaluation of anJournal of labelled compounds & radiopharmaceuticals · 2016
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Narasimharao NalabothulaMarlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, School of Medicine, Department of Radiation Oncology, Baltimore, Maryland.
Fred E Indig
France Carrier

Funding

NIA/RRB Confocal Imaging FacilityZICAG000615 · NIA · NATIONAL INSTITUTE ON AGING · PI INDIG, FRED · 2009 to 2025
$17.9M
Biomodulation of anticancer drugs targeting DNAR01CA116491 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI CARRIER, FRANCE · 2007 to 2009
$684k
NCI NIH HHS R01 CA116491
6 · The paper itself

Abstract

The nucleolus is a highly dynamic nuclear substructure that was originally described as the site of ribosome biogenesis. The advent of proteomic analysis has now allowed the identification of over 4500 nucleolus associated proteins with only about 30% of them associated with ribogenesis (1). The great number of nucleolar proteins not associated with traditionally accepted nucleolar functions indicates a role for the nucleolus in other cellular functions such as mitosis, cell-cycle progression, cell proliferation and many forms of stress response including DNA repair (2). A number of recent reviews have addressed the pivotal role of the nucleolus in the cellular stress response (1, 3, 4). Here, we will focus on the role of Nucleolin and Nucleophosmin, two major components of the nucleolus, in response to genotoxic stress. Due to space constraint only a limited number of studies are cited. We thus apologize to all our colleagues whose works are not referenced here.

Identifiers

PMID21499571
PMCPMC3076688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.