Evidence map›Paper›PMID 21499510›Full record

ArticleChemistry of materials : a publication of the American Chemical Society2011

Stöber Synthesis of Nitric Oxide-Releasing S-Nitrosothiol-Modified Silica Particles.

Daniel A Riccio, Julia L Nugent, Mark H Schoenfisch

Open access · greenAbstract read
In one paragraph

Article in Chemistry of materials : a publication of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 93 citations in OpenAlex.

  1. Review
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  5. Review
  6. Nitric oxide releasing halloysite nanotubes for biomedical applications.Journal of colloid and interface science · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Article
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  12. Article
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  14. Review
  15. Polymer chemistry · 2016
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Daniel A RiccioDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Julia L Nugent
Mark H Schoenfisch
University of North Carolina at Chapel Hill · US

Funding

Nitric Oxide-Releasing Glucose BiosensorsR01EB000708 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHOENFISCH, MARK H · 2002 to 2011
$3.1M
NIBIB NIH HHS R01 EB000708
6 · The paper itself

Abstract

We report the synthesis of S-nitrosothiol-modified silica particles capable of nitric oxide (NO) release. The thiol precursor modification to form S-nitrosothiol NO donors was introduced into the silica network via co-condensation of mercaptosilane and alkoxysilane precursors. Both the concentrations of reactants (i.e., water, ammonia, and silane) and the silane feed rate into the reaction proved important in the yield of monodisperse, spherical particles with tunable diameters ranging from 241-718 nm. Subsequent nitrosation resulted in NO storage approaching ~4.40 μmol NO mg(-1), as determined by total NO release. Behaving similar to low molecular weight S-nitrosothiol NO donors, the NO release from the macromolecular silica vehicles was influenced by light, temperature, and metal ions.

Identifiers

PMID21499510
PMCPMC3075092
OpenAlexW2019345099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.