ArticleNature2011
Stem-cell-triggered immunity through CLV3p-FLS2 signalling.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 85 citations in OpenAlex.
- Peptide hormones in plants.Molecular horticulture · 2025Review
- CLE peptide signaling in plant-microbe interactions.Frontiers in plant science · 2024Review
- Integrated Framework of the Immune-Defense Transcriptional Signatures in the Arabidopsis Shoot Apical Meristem.International journal of molecular sciences · 2020Article
- Mitogen-activated protein kinases MPK3 and MPK6 are required for stem cell maintenance in the Arabidopsis shoot apical meristem.Plant cell reports · 2019Article
- The SCOOP12 peptide regulates defense response and root elongation in Arabidopsis thaliana.Journal of experimental botany · 2019Article
- Plant peptides in plant defense responses.Plant signaling & behavior · 2018Review
- Article
- The IDA-LIKE peptides IDL6 and IDL7 are negative modulators of stress responses in Arabidopsis thaliana.Journal of experimental botany · 2017Article
- Carbonic Anhydrases Function in Anther Cell Differentiation Downstream of the Receptor-Like Kinase EMS1.The Plant cell · 2017Article
- Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling.Frontiers in plant science · 2017Review
- Challenges in the identification of microbe-associated molecular patterns in plant and animal innate immunity: a case study with bacterial lipopolysaccharide.Molecular plant pathology · 2016Article
- Q&A: How does peptide signaling direct plant development?BMC biology · 2016Article
- GRIM REAPER peptide binds to receptor kinase PRK5 to trigger cell death in Arabidopsis.The EMBO journal · 2015Article
- Low temperature conditioning of garlic (Allium sativum L.) "seed" cloves induces alterations in sprouts proteome.Frontiers in plant science · 2015Article
- Phosphoproteomics-based peptide ligand-receptor kinase pairing. Commentary on: "A peptide hormone and its receptor protein kinase regulate plant cell expansion".Frontiers in plant science · 2015Article
- The secreted peptide PIP1 amplifies immunity through receptor-like kinase 7.PLoS pathogens · 2014Article
- Stem-cell-triggered immunity safeguards cytokinin enriched plant shoot apexes from pathogen infection.Frontiers in plant science · 2014Article
- Identification of immunity-related genes in Arabidopsis and cassava using genomic data.Genomics, proteomics & bioinformatics · 2013Article
- Recognition of bacterial plant pathogens: local, systemic and transgenerational immunity.The New phytologist · 2013Review
- Submergence confers immunity mediated by the WRKY22 transcription factor in Arabidopsis.The Plant cell · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stem cells in the shoot apical meristem (SAM) of plants are the self-renewable reservoir for leaf, stem and flower organogenesis. In nature, disease-free plants can be regenerated from SAM despite infections elsewhere, which underlies a horticultural practice for decades. However, the molecular basis of the SAM immunity remains unclear. Here we show that the CLAVATA3 peptide (CLV3p), expressed and secreted from stem cells and functioning as a key regulator of stem-cell homeostasis in the SAM of Arabidopsis, can trigger immune signalling and pathogen resistance via the flagellin receptor kinase FLS2 (refs 5, 6). CLV3p-FLS2 signalling acts independently from the stem-cell signalling pathway mediated through CLV1 and CLV2 receptors, and is uncoupled from FLS2-mediated growth suppression. Endogenous CLV3p perception in the SAM by a pattern recognition receptor for bacterial flagellin, FLS2, breaks the previously defined self and non-self discrimination in innate immunity. The dual perception of CLV3p illustrates co-evolution of plant peptide and receptor kinase signalling for both development and immunity. The enhanced immunity in SAM or germ lines may represent a common strategy towards immortal fate in plants and animals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.