ArticleRetina (Philadelphia, Pa.)
Ten-year follow-up of eyes treated with stereotactic fractionated external beam radiation for neovascular age-related macular degeneration.
Article in Retina (Philadelphia, Pa.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Risk of scar in the comparison of age-related macular degeneration treatments trials.Ophthalmology · 2014Trial
- Solitary choroidal metastasis of distal cholangiocarcinoma: A case report.Oncology letters · 2023Article
- Adaptive optics scanning laser ophthalmoscopy and optical coherence tomography (AO-SLO-OCT) system forBiomedical optics express · 2023Article
- The effects of Nigella sativa oil, thymoquinone, propolis, and caffeic acid phenethyl ester on radiation-induced cataract.Wiener klinische Wochenschrift · 2016Article
- Acute and late toxicity of bilateral orbital irradiation in the management of primary intraocular lymphoma.Leukemia & lymphoma · 2016Article
- Context for Protons as Adjunctive Therapy in Neovascular Age-Related Macular Degeneration: A Review.International journal of particle therapy · 2016Review
- [Adjuvant stereotactic low energy radiation therapy of exudative age-dependent macular degeneration (Oraya system)].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2013Article
- Complete regression of a choroidal metastasis secondary to breast cancer with stereotactic radiation: case report and review of literature.Journal of radiosurgery and SBRT · 2013Article
- Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium.The oncologist · 2011Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine the long-term effects of stereotactic fractionated external beam radiation on eyes treated for neovascular age-related macular degeneration.
methodsA retrospective review of all eyes treated with stereotactic fractionated external beam radiation (20-40 Gy, 2-Gy fractions) between 1997 and 2000 was performed to identify eyes with ≥ 2-year follow-up for analysis. A subset was imaged prospectively using a high-resolution Fourier-domain optical coherence tomography.
resultsAmong 94 eyes treated, 33 eyes (32 subjects) had ≥ 2-year follow-up information (mean follow-up, 6.2 years; range, 2-10 years). Final visual acuity ranged from 20/50 to no light perception. Final macular findings included central geographic atrophy (49%), disciform scar (30%), and active choroidal neovascular membrane (9%). Fourier-domain optical coherence tomography images of three eyes with geographic atrophy revealed photoreceptor layer loss within areas of geographic atrophy with intact retinal morphology in areas of radiation exposure outside geographic atrophy. Radiation retinopathy was suspected in 18% and confirmed by fluorescein angiography in 15%, ranging from mild to neovascular glaucoma/phthisis bulbi (2 eyes). Mean time from stereotactic fractionated external beam radiation to development of radiation retinopathy was 5.4 years (range, 1-10 years).
conclusionA moderate rate of delayed radiation retinopathy was noted in eyes with neovascular age-related macular degeneration treated with stereotactic fractionated external beam radiation. Geographic atrophy was a common finding.
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