Trial reportPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2012
Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy.
Trial report in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Neonatal encephalopathy: a systematic review of reported treatment outcomes.BMJ paediatrics open · 2024Pooled it
- Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis.Journal of global health · 2022Pooled it
- Pooled it
- Cooling for newborns with hypoxic ischaemic encephalopathy.The Cochrane database of systematic reviews · 2013Pooled it
- Trial
- Temperature control during therapeutic hypothermia for newborn encephalopathy using different Blanketrol devices.Therapeutic hypothermia and temperature management · 2014Trial
- Whole-body vs. selective head cooling and target temperature strategies for neonatal HIE: a meta-analysis of long-term outcomes.Frontiers in pediatrics · 2026Review
- Servo-controlled therapeutic hypothermia during neonatal transport: a before-and-after quality improvement project.European journal of pediatrics · 2024Observational
- Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network.Seminars in perinatology · 2022Review
- Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Sex Differences in Brain Injury and Repair in Newborn Infants: Clinical Evidence and Biological Mechanisms.Frontiers in pediatrics · 2019Review
- Therapeutic Hypothermia: How Can We Optimize This Therapy to Further Improve Outcomes?Clinics in perinatology · 2018Review
- Ischemic Conditioning and neonatal hypoxic ischemic encephalopathy: a literature review.Conditioning medicine · 2017Article
- Relationship between temperature variability and brain injury on magnetic resonance imaging in cooled newborn infants after perinatal asphyxia.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Initiation of passive cooling at referring centre is most predictive of achieving early therapeutic hypothermia in asphyxiated newborns.Paediatrics & child health · 2017Article
- Safety and Short-Term Outcomes of Therapeutic Hypothermia in Preterm Neonates 34-35 Weeks Gestational Age with Hypoxic-Ischemic Encephalopathy.The Journal of pediatrics · 2017Article
- Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field.Seminars in perinatology · 2016Review
- A new approach to define acute kidney injury in term newborns with hypoxic ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2016Article
- HMGB1 Translocation After Ischemia in the Ovine Fetal Brain.Journal of neuropathology and experimental neurology · 2016Article
- A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest.Resuscitation · 2014Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundDecreases below the target temperature were noted among neonates undergoing cooling in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Trial of whole body hypothermia for neonatal hypoxic-ischemic encephalopathy.
objectiveTo examine the temperature profile and impact on outcome among ≥ 36 wk gestation neonates randomized at ≤ 6 hrs of age targeting an esophageal temperature of 33.5°C for 72 hrs. DESIGN, SETTING, PATIENTS: Infants with intermittent temperatures recorded of <32.0°C during induction and maintenance of cooling were compared to all other cooled infants, and the relationship with outcome at 18 months was evaluated.
interventionsNone. MEASUREMENTS AND MAIN
resultsThere were no differences in the stage of encephalopathy, acidosis, or 10 min Apgar scores between infants with temperatures of <32.0°C during induction (n = 33) or maintenance (n = 10) and all other infants who were cooled (n = 58); however, birth weight was lower and the need for blood pressure support higher among infants with temperatures of <32.0°C compared to all other cooled infants. No increase in acute adverse events was noted among infants with temperatures of <32.0°C, and hours spent at <32°C was not associated with the primary outcome of death or moderate/severe disability or the Bayley II Mental Developmental Index at 18 months.
conclusionsTerm infants with a lower birth weight are at risk for decreasing temperatures of <32.0°C while undergoing body cooling using a servo-controlled system. This information suggests extra caution during the application of hypothermia as these lower birth weight infants are at risk for overcooling. Our findings may assist in planning additional trials of lower target temperature for neonatal hypoxic-ischemic encephalopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.