ArticleJournal of acquired immune deficiency syndromes (1999)2011
Predictors of CD4 eligibility for antiretroviral therapy initiation among HIV-infected pregnant women in Lusaka, Zambia.
Article in Journal of acquired immune deficiency syndromes (1999), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Underutilisation of routinely collected data in the HIV programme in Zambia: a review of quantitatively analysed peer-reviewed articles.Health research policy and systems · 2017Review
- Impact of expanded access to combination antiretroviral therapy in pregnancy: results from a cohort study in Ukraine.Bulletin of the World Health Organization · 2013Article
- Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy.International journal of STD & AIDS · 2013Article
- Nonvirologic algorithms for predicting HIV infection among HIV-exposed infants younger than 12 weeks of age.The Pediatric infectious disease journal · 2013Article
- Mortality and health outcomes of HIV-exposed and unexposed children in a PMTCT cohort in Malawi.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIn resource-limited settings, CD4 testing is a barrier to antiretroviral therapy initiation in pregnancy.
methodsWe used logistic regression to identify predictors of CD4 cell count ≤ 350 cells/uL in 20,233 pregnant women.
resultsThe best-performing model included any 3 of: age ≥ 28 years old, hemoglobin ≤ 9.8 g/dL, gestational age ≤ 30 weeks, weight ≤ 64 kg, history of tuberculosis or previous death of an infant prior to one year old. Sensitivity was 45.7% (95% CI: 44.5-47.0), specificity 70.7% (95% CI: 69.6-71.8), and misclassification rate 41.4% (95% CI: 40.5-42.2).
conclusionCD4 triage remains a critical element of maternal HIV care and PMTCT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.