ArticleJournal of epidemiology2011
Genetic heterogeneity of self-reported ancestry groups in an admixed Brazilian population.
Article in Journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Trial
- The influence of CHRNA5 and D398N missense variation on social and emotional behaviors in rodents and humans.Translational psychiatry · 2025Article
- Ancestry estimation in forensic anthropology: accuracy of the AncesTrees software in a Brazilian sample.Forensic sciences research · 2023Article
- Alpha thalassemia and alpha-MRE haplotypes in Uruguayan patients with microcytosis and hypochromia without anemia.Genetics and molecular biology · 2021Article
- How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians.Frontiers in immunology · 2020Article
- An Interactive Resource to Probe Genetic Diversity and Estimated Ancestry in Cancer Cell Lines.Cancer research · 2019Review
- Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry.Genetica · 2016Article
- ACVR1B rs2854464 Is Associated with Sprint/Power Athletic Status in a Large Cohort of Europeans but Not Brazilians.PloS one · 2016Article
- The correlation between ancestry and color in two cities of Northeast Brazil with contrasting ethnic compositions.European journal of human genetics : EJHG · 2015Article
- Relations of digital vascular function, cardiovascular risk factors, and arterial stiffness: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort study.Journal of the American Heart Association · 2014Observational
- Association between polymorphisms in the TRHR gene, fat-free mass, and muscle strength in older women.Age (Dordrecht, Netherlands) · 2013Article
- The relationship between lymphatic vascular density and vascular endothelial growth factor A (VEGF-A) expression with clinical-pathological features and survival in pancreatic adenocarcinomas.Diagnostic pathology · 2013Article
- HAART-associated dyslipidemia varies by biogeographical ancestry in the multicenter AIDS cohort study.AIDS research and human retroviruses · 2013Article
- Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.PloS one · 2013Article
- Article
- Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women.Genetics and molecular biology · 2012Article
- Human leukocyte antigen profiles of latin american populations: differential admixture and its potential impact on hematopoietic stem cell transplantation.Bone marrow research · 2012Article
- Genomic ancestry, self-reported "color" and quantitative measures of skin pigmentation in Brazilian admixed siblings.PloS one · 2011Article
- A systematic scoping review of the genetic ancestry of the Brazilian population.Genetics and molecular biologyArticle
- The impact ofAlzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPopulation stratification is the main source of spurious results and poor reproducibility in genetic association findings. Population heterogeneity can be controlled for by grouping individuals in ethnic clusters; however, in admixed populations, there is evidence that such proxies do not provide efficient stratification control. The aim of this study was to evaluate the relation of self-reported with genetic ancestry and the statistical risk of grouping an admixed sample based on self-reported ancestry.
methodsA questionnaire that included an item on self-reported ancestry was completed by 189 female volunteers from an admixed Brazilian population. Individual genetic ancestry was then determined by genotyping ancestry informative markers.
resultsSelf-reported ancestry was classified as white, intermediate, and black. The mean difference among self-reported groups was significant for European and African, but not Amerindian, genetic ancestry. Pairwise fixation index analysis revealed a significant difference among groups. However, the increase in the chance of type 1 error was estimated to be 14%.
conclusionsSelf-reporting of ancestry was not an appropriate methodology to cluster groups in a Brazilian population, due to high variance at the individual level. Ancestry informative markers are more useful for quantitative measurement of biological ancestry.
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