ArticleEukaryotic cell2011
Self-induction of a/a or alpha/alpha biofilms in Candida albicans is a pheromone-based paracrine system requiring switching.
Article in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Glucose depletion enables Candida albicans mating independently of the epigenetic white-opaque switch.Nature communications · 2023Article
- The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.Genome biology · 2019Article
- Autocrine pheromone signalling regulates community behaviour in the fungal pathogen Fusarium oxysporum.Nature microbiology · 2019Article
- Binding Sites in the EFG1 Promoter for Transcription Factors in a Proposed Regulatory Network: A Functional Analysis in the White and Opaque Phases of Candida albicans.G3 (Bethesda, Md.) · 2016Article
- Candida albicans the chameleon: transitions and interactions between multiple phenotypic states confer phenotypic plasticity.Current opinion in microbiology · 2015Review
- Role of Tec1 in the development, architecture, and integrity of sexual biofilms of Candida albicans.Eukaryotic cell · 2015Article
- Sexual reproduction of human fungal pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- Sexual biofilm formation in Candida tropicalis opaque cells.Molecular microbiology · 2014Article
- The role of phenotypic switching in the basic biology and pathogenesis of Candida albicans.Journal of oral microbiology · 2014Review
- Recent insights into Candida albicans biofilm resistance mechanisms.Current genetics · 2013Review
- Impact of environmental conditions on the form and function of Candida albicans biofilms.Eukaryotic cell · 2013Article
- Candida albicans forms a specialized "sexual" as well as "pathogenic" biofilm.Eukaryotic cell · 2013Article
- Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms.Eukaryotic cell · 2013Article
- Review
- Communication in fungi.International journal of microbiology · 2012Article
- Alternative mating type configurations (a/α versus a/a or α/α) of Candida albicans result in alternative biofilms regulated by different pathways.PLoS biology · 2011Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
Like MTL-heterozygous (a/α) cells, white MTL-homozygous (a/a or α/α) cells of Candida albicans, to which a minority of opaque cells of opposite mating type have been added, form thick, robust biofilms. The latter biofilms are uniquely stimulated by the pheromone released by opaque cells and are regulated by the mitogen-activated protein kinase signal transduction pathway. However, white MTL-homozygous cells, to which opaque cells of opposite mating type have not been added, form thinner biofilms. Mutant analyses reveal that these latter biofilms are self-induced. Self-induction of a/a biofilms requires expression of the α-receptor gene STE2 and the α-pheromone gene MFα, and self-induction of α/α biofilms requires expression of the a-receptor gene STE3 and the a-pheromone gene MFa. In both cases, deletion of WOR1, the master switch gene, blocks cells in the white phenotype and biofilm formation, indicating that self-induction depends upon low frequency switching from the white to opaque phenotype. These results suggest a self-induction scenario in which minority opaque a/a cells formed by switching secrete, in a mating-type-nonspecific fashion, α-pheromone, which stimulates biofilm formation through activation of the α-pheromone receptor of majority white a/a cells. A similar scenario is suggested for a white α/α cell population, in which minority opaque α/α cells secrete a-pheromone. This represents a paracrine system in which one cell type (opaque) signals a second highly related cell type (white) to undergo a complex response, in this case the formation of a unisexual white cell biofilm.
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