ArticleClinical cancer research : an official journal of the American Association for Cancer Research2011
New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- The biology and therapeutic implications of heterogeneity in Barrett oesophagus and oesophageal adenocarcinoma.Nature reviews. Clinical oncology · 2026Review
- BRCA mutations and gastrointestinal cancers: When to expect the unexpected?World journal of clinical oncology · 2021Review
- European Laryngological Society position paper on laryngeal dysplasia Part I: aetiology and pathological classification.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Review
- Molecular Evolution of Metaplasia to Adenocarcinoma in the Esophagus.Digestive diseases and sciences · 2018Review
- Article
- Genomics, Endoscopy, and Control of Gastroesophageal Cancers: A Perspective.Cellular and molecular gastroenterology and hepatology · 2017Review
- Bulk Genotyping of Biopsies Can Create Spurious Evidence for Hetereogeneity in Mutation Content.PLoS computational biology · 2016Article
- Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion.Nature communications · 2016Article
- Genetic Insights in Barrett's Esophagus and Esophageal Adenocarcinoma.Gastroenterology · 2015Review
- Barrett oesophagus: lessons on its origins from the lesion itself.Nature reviews. Gastroenterology & hepatology · 2015Review
- High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett's Esophagus.PloS one · 2015Article
- The Barrett's Gland in Phenotype Space.Cellular and molecular gastroenterology and hepatology · 2015Review
- Hereditary Factors in Esophageal Adenocarcinoma.Gastrointestinal tumors · 2014Review
- Assessment of mutational load in biopsy tissue provides additional information about genomic instability to histological classifications of Barrett's esophagus.Journal of gastrointestinal cancer · 2014Article
- Identifying signatures of selection in genetic time series.Genetics · 2014Article
- Global changes in gene expression of Barrett's esophagus compared to normal squamous esophagus and gastric cardia tissues.PloS one · 2014Article
- NSAIDs modulate clonal evolution in Barrett's esophagus.PLoS genetics · 2013Article
- DNA methylation as an adjunct to histopathology to detect prevalent, inconspicuous dysplasia and early-stage neoplasia in Barrett's esophagus.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Single-cell analysis reveals early manifestation of cancerous phenotype in pre-malignant esophageal cells.PloS one · 2013Article
- Correlation of the presence and extent of loss of heterozygosity mutations with histological classifications of Barrett's esophagus.BMC gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Barrett's esophagus is a condition in which the normal stratified squamous epithelium of the distal esophagus is replaced by intestinal metaplasia. For more than three decades, the prevailing clinical paradigm has been that Barrett's esophagus is a complication of symptomatic reflux disease that predisposes to esophageal adenocarcinoma. However, no clinical strategy for cancer prevention or early detection based on this paradigm has been proven to reduce esophageal adenocarcinoma mortality in a randomized clinical trial in part because only about 5% to 10% of individuals with Barrett's esophagus develop esophageal adenocarcinoma. Recent research indicates that Barrett's metaplasia is an adaptation for mucosal defense in response to chronic reflux in most individuals. The risk of progressing to esophageal adenocarcinoma is determined by development of genomic instability and dynamic clonal evolution in the distal esophagus modulated by host and environmental risk and protective factors, including inherited genotype. The challenge for investigators of Barrett's esophagus lies in integrating knowledge about genomic instability and clonal evolution into clinical management to increase the lifespan and quality of life of individuals with this condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.