Evidence map›Paper›PMID 21497949›Full record

ArticleNeurobiology of aging2011

The epigenetics of Alzheimer's disease--additional considerations.

Joseph Rogers, Diego Mastroeni, Andrew Grover, Elaine Delvaux, Charisse Whiteside, Paul D Coleman

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neurobiology of aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration.Biochimica et biophysica acta. Molecular basis of disease · 2018
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph RogersBanner Sun Health Research Institute, Sun City, AZ, USA. joseph.rogers@bannerhealth.com
Diego Mastroeni
Andrew Grover
Elaine Delvaux
Charisse Whiteside
Paul D Coleman
Banner Sun Health Research Institute · USBanner Health · US

Funding

PRESENCE AND ROLE OF IMMUNE MARKERS IN ALZHEIMER'S BRAINR01AG007367 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI ROGERS, JOSEPH B · 1988 to 2014
$3.3M
DNA methylation in Alzheimer?s disease and normally aged brainR01AG036400 · NIA · BANNER SUN HEALTH RESEARCH INSTITUTE · PI COLEMAN, PAUL D · 2009 to 2013
$2.0M
Alzheimer's disease: a blood diagnostic and biomarker of disease progressionR56AG007367 · NIA · BANNER SUN HEALTH RESEARCH INSTITUTE · PI ROGERS, JOSEPH B · 2010 to 2011
$594k
NIA NIH HHS AG 036400NIA NIH HHS AG 07367-19NIA NIH HHS R01 AG036400
6 · The paper itself

Abstract

The critical commentaries following our review of the epigenetics of Alzheimer's disease (AD) amplify a number of key points with respect to the role of 1-carbon metabolism, the phenomenon of allele-specific methylation, the potentially critical explanatory link provided by epigenetic mechanisms for genome-wide association and large-scale gene expression array studies, and new therapeutic approaches afforded by epigenetic manipulation in Alzheimer's disease.

Indexed as

Alzheimer DiseaseAnimalsDNA MethylationEpigenesis, GeneticGenetic Predisposition to DiseaseHumansMolecular BiologyOne-Carbon Group TransferasesTranslational Research, BiomedicalOne-Carbon Group Transferases

Identifiers

PMID21497949
OpenAlexW2100235682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.