ArticleNeurobiology of aging2011
Toward an integrated genetic and epigenetic approach to Alzheimer's disease.
Article in Neurobiology of aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.Molecular neurobiology · 2016Pooled it
- Histone Deacetylation in Alzheimer's Diseases (AD); Hope or Hype.Cell biochemistry and biophysics · 2025Review
- Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- A Review of the Recent Advances in Alzheimer's Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics.Diagnostics (Basel, Switzerland) · 2022Review
- The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease.Epigenomes · 2021Review
- Hypermethylation ofOxidative medicine and cellular longevity · 2018Article
- DNMT3A rs1550117 Polymorphism is Associated With Late-Onset Alzheimer's Disease in a Chinese Population.American journal of Alzheimer's disease and other dementias · 2016Article
- Epigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug Response.International journal of molecular sciences · 2015Review
- The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015Review
- Epigenetic nutraceutical diets in Alzheimer's disease.The journal of nutrition, health & aging · 2014Review
- Peripheral blood mononuclear cells as a laboratory to study dementia in the elderly.BioMed research international · 2014Review
- Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Review
- Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease.Pharmacology & therapeutics · 2013Review
- Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics.Current Alzheimer research · 2012Review
- Using DNA methylation to understand biological consequences of genetic variability.Neuro-degenerative diseases · 2012Review
- Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex.Journal of Alzheimer's disease : JAD · 2012Article
- Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease.Molecular neurodegeneration · 2011Article
- The impact of childhood maltreatment: a review of neurobiological and genetic factors.Frontiers in psychiatry · 2011Article
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1 author at 1 institution in 1 country.
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Abstract
Epigenetics is the study of mitotically heritable, but reversible, changes in gene expression brought about principally through alterations in DNA methylation and chromatin structure. The comprehensive review by Mastroeni et al. (Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P., Rogers, J., 2010. Epigenetic mechanisms in Alzheimer's disease. Neurobiol. Aging, doi:10.1016/j.neurobiolaging.2010.08.017) in this issue describes mounting evidence for an involvement of epigenetic alterations in the etiology of Alzheimer's disease (AD), highlighting the potential of epigenomic approaches for uncovering novel molecular pathways involved in pathology. Here, we briefly describe some methodological issues related to epigenomic studies using postmortem brain tissue in Alzheimer's disease, and argue for an integrated genetic-epigenetic approach to disease etiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.