ArticleBiological psychiatry2011
A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings.
Article in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Genetic Factors That Could Affect Concussion Risk in Elite Rugby.Sports (Basel, Switzerland) · 2021Review
- Metabolic, Molecular, and Behavioral Effects of Western Diet in Serotonin Transporter-Deficient Mice: Rescue by Heterozygosity?Frontiers in neuroscience · 2020Article
- Protein-protein interactions underlying the behavioral and psychological symptoms of dementia (BPSD) and Alzheimer's disease.PloS one · 2020Article
- Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.Experimental and clinical psychopharmacology · 2019Article
- Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study.Croatian medical journal · 2018Article
- Tandem repeats mediating genetic plasticity in health and disease.Nature reviews. Genetics · 2018Review
- Pharmacogenetics of Cannabinoids.European journal of drug metabolism and pharmacokinetics · 2018Review
- Fractionating impulsivity: neuropsychiatric implications.Nature reviews. Neuroscience · 2017Review
- Attention-Deficit/Hyperactivity Disorder and Monetary Delay Discounting: A Meta-Analysis of Case-Control Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Moving towards causality in attention-deficit hyperactivity disorder: overview of neural and genetic mechanisms.The lancet. Psychiatry · 2016Review
- The Association Between Breastfeeding Exposure and Duration, Neuropsychological Deficits, and Psychopathic Personality Traits in Offspring: The Moderating Role of 5HTTLPR.The Psychiatric quarterly · 2016Article
- Role of serotonin transporter function in rat orbitofrontal cortex in impulsive choice.Behavioural brain research · 2015Article
- Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency.Behavioural brain research · 2015Article
- Serotonin transporter polymorphism (5-HTTLPR) in Croatian population.Molecular biology reports · 2015Article
- Development of Ego-Resiliency: Relations to Observed Parenting and Polymorphisms in the Serotonin Transporter Gene During Early Childhood.Social development (Oxford, England) · 2014Article
- Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.Movement disorders : official journal of the Movement Disorder Society · 2013Article
- COMT val158met and 5-HTTLPR genetic polymorphisms moderate executive control in cannabis users.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Genetics of impulsive behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Early pathogenic care and the development of ADHD-like symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
Corrections and comments
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Authors and funding
26 authors at 17 institutions in 10 countries.
Funding
Abstract
backgroundImpulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with dopamine regulating genes and delay aversion would be associated with serotonin-regulating genes.
methodsImpulsive drive for immediate reward and delay aversion were measured in 459 male children and adolescents (328 ADHD and 131 unaffected siblings) with a laboratory choice task. The sample was genotyped for the 5HTT (SLC6A4) promoter serotonin-transporter-linked polymorphic region polymorphism and a DAT1 (SLC6A3) 40-base pair variable number tandem repeat located in the 3'-untranslated region of the gene.
resultsThere was no effect of dopamine transporter (DAT)1 on IDIR. As predicted, serotonin-transporter-linked polymorphic region s-allele carriers were more delay averse. This effect was driven by the s/l genotype in the ADHD group. These results were not altered by taking account of the rs25531 A/G single nucleotide polymorphism and were independent of age, IQ, and oppositional defiant disorder symptoms.
conclusionsThe results support the genetic distinctiveness of IDIR and delay aversion in ADHD and implicate serotonin function in delay aversion. Possible explanations of the heterosis effect in the ADHD cases are presented.
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