ArticleDevelopmental cell2011
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility.
Article in Developmental cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 1 of them a synthesis that pooled it.
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Who cites it
112 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration.BMC developmental biology · 2011Pooled it
- Internalized Evolutionary Inertia on Body Plan Evolution.Evolution & development · 2026Review
- Toward mechanisms underlying the developmental hourglass: evolvability and phylotypic conservation.EvoDevo · 2025Review
- Cell type-independent timekeeping gene modules enable embryonic stage prediction in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Unraveling developmental gene regulation in holometabolous insects through comparative transcriptomics and proteomics.Communications biology · 2025Article
- High-resolution transcriptome datasets during embryogenesis of plant-parasitic nematodes.Scientific data · 2024Article
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- Small molecule-mediated reprogramming of Xenopus blastula stem cells to a neural crest state.Developmental biology · 2024Article
- The sulfotransferase XB5850668.L is required to apportion embryonic ectodermal domains.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Deep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus.BMC biology · 2023Article
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- Evolutionary mechanisms modulating the mammalian skull development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Stability in gene expression and body-plan development leads to evolutionary conservation.EvoDevo · 2023Article
- Characterization of a novel corticosterone response gene inFrontiers in endocrinology · 2023Article
- Nascent transcriptome reveals orchestration of zygotic genome activation in early embryogenesis.Current biology : CB · 2022Article
- Insulin Receptor-Related Receptor Regulates the Rate of Early Development inInternational journal of molecular sciences · 2022Article
- Potential contribution of intrinsic developmental stability toward body plan conservation.BMC biology · 2022Article
- Distinguishing Evolutionary Conservation from Derivedness.Life (Basel, Switzerland) · 2022Review
- Enhanced Loss of Retinoic Acid Network Genes inCells · 2022Article
52 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Changes in gene expression are thought to be important for morphological evolution, though little is known about the nature or magnitude of the differences. Here, we examine Xenopus laevis and Xenopus tropicalis, two amphibians with very similar development, and ask how their transcriptomes compare. Despite separation for ~30-90 million years, there is strong conservation in gene expression in the vast majority of the expressed orthologs. Significant changes occur in the level of gene expression but changes in the timing of expression (heterochrony) were much less common. Differences in level were concentrated in the earliest embryonic stages. Changes in timing were prominently found in pathways that respond to selective features of the environment. We propose that different evolutionary rates across developmental stages may be explained by the stabilization of cell fate determination in the later stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.