ArticleActa tropica2011
High genetic polymorphism of relapsing P. vivax isolates in northwest Colombia.
Article in Acta tropica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Resolving the cause of recurrent Plasmodium vivax malaria probabilistically.Nature communications · 2019Trial
- Parasite genotypes and host immune mediators in primary and recurrent episodes of vivax Malaria in Colombia.Revista peruana de medicina experimental y salud publica · 2025Article
- Genetic diversity ofLancet regional health. Americas · 2023Article
- Population-level genome-wide STR discovery and validation for population structure and genetic diversity assessment of Plasmodium species.PLoS genetics · 2022Article
- Review
- Molecular and immunological analyses of confirmed Plasmodium vivax relapse episodes.Malaria journal · 2017Article
- High Efficacy of Primaquine Treatment for Plasmodium vivax in Western Thailand.The American journal of tropical medicine and hygiene · 2016Article
- Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses.PloS one · 2016Article
- Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse.The Journal of infectious diseases · 2015Article
- Assessment of an automated capillary system for Plasmodium vivax microsatellite genotyping.Malaria journal · 2015Article
- The utility of genomic data for Plasmodium vivax population surveillance.Pathogens and global health · 2015Review
- Plasmodium vivax Diversity and Population Structure across Four Continents.PLoS neglected tropical diseases · 2015Article
- Genetic variation and recurrent parasitaemia in Peruvian Plasmodium vivax populations.Malaria journal · 2014Article
- Population structure and spatio-temporal transmission dynamics of Plasmodium vivax after radical cure treatment in a rural village of the Peruvian Amazon.Malaria journal · 2014Article
- A call to arms: on refining Plasmodium vivax microsatellite marker panels for comparing global diversity.Malaria journal · 2013Article
- Plasmodium vivax isolates from Cambodia and Thailand show high genetic complexity and distinct patterns of P. vivax multidrug resistance gene 1 (pvmdr1) polymorphisms.The American journal of tropical medicine and hygiene · 2013Article
- A high force of plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in papua new guinean children.PLoS neglected tropical diseases · 2013Article
- Local population structure of Plasmodium: impact on malaria control and elimination.Malaria journal · 2012Article
- Genotype comparison of Plasmodium vivax and Plasmodium falciparum clones from pregnant and non-pregnant populations in North-west Colombia.Malaria journal · 2012Article
- Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse.Journal of clinical microbiology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic diversity of Plasmodium populations has been more extensively documented in Colombia for Plasmodium falciparum than for Plasmodium vivax. Recently, highly variable microsatellite markers have been described and used in population-level studies of genetic variation of P. vivax throughout the world. We applied this approach to understand the genetic structure of P. vivax populations and to identify recurrence-associated haplotypes. In this, three microsatellite markers of P. vivax were amplified and the combined size of the fragments was used to establish genotypes. Patients from an ongoing treatment efficacy trial who were kept either in endemic or non-endemic regions in the northwest of Colombia were included in the study. In total 58 paired clinical isolates, were amplified. A total of 54 haplotypes were observed among the two regions. Some haplotypes were exclusive to the endemic region where the highest degree of polymorphism was detected. In addition, we confirmed the different genotypes of recurrent-relapsing and primary infection isolates suggesting the activation of heterologous hypnozoite populations. We conclude that analysis of the three microsatellites is a valuable tool to establish the genetic characteristics of P. vivax populations in Colombia.
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