ArticleDevelopmental biology2011
A search for factors specifying tonotopy implicates DNER in hair-cell development in the chick's cochlea.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.PLoS genetics · 2012Pooled it
- Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity.Journal of biomedical science · 2025Article
- Alternative splicing in shaping the molecular landscape of the cochlea.Frontiers in cell and developmental biology · 2023Review
- Position Specific Alternative Splicing and Gene Expression Profiles Along the Tonotopic Axis of Chick Cochlea.Frontiers in molecular biosciences · 2021Article
- Pleiotrophin increases neurite length and number of spiral ganglion neurons in vitro.Experimental brain research · 2019Article
- DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina.The Journal of comparative neurology · 2018Article
- DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway.Molecular medicine reports · 2018Article
- Bioinformatic Integration of Molecular Networks and Major Pathways Involved in Mice Cochlear and Vestibular Supporting Cells.Frontiers in molecular neuroscience · 2018Article
- Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence.BMC genomics · 2016Article
- Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Expression and Misexpression of the miR-183 Family in the Developing Hearing Organ of the Chicken.PloS one · 2015Article
- Using injectoporation to deliver genes to mechanosensory hair cells.Nature protocols · 2014Article
- Lessons learned from vivo-morpholinos: How to avoid vivo-morpholino toxicity.BioTechniques · 2014Article
- The very large G protein coupled receptor (Vlgr1) in hair cells.Journal of molecular neuroscience : MN · 2013Review
- Protocadherin-17 function in Zebrafish retinal development.Developmental neurobiology · 2013Article
- Article
- Heterogeneous nuclear ribonucleoprotein K, an RNA-binding protein, is required for optic axon regeneration in Xenopus laevis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.PloS one · 2012Article
- Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.PLoS biology · 2012Article
- Developmental regulation of planar cell polarity and hair-bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The accurate perception of sound frequency by vertebrates relies upon the tuning of hair cells, which are arranged along auditory organs according to frequency. This arrangement, which is termed a tonotopic gradient, results from the coordination of many cellular and extracellular features. Seeking the mechanisms that orchestrate those features and govern the tonotopic gradient, we used expression microarrays to identify genes differentially expressed between the high- and low-frequency cochlear regions of the chick (Gallus gallus). Of the three signaling systems that were represented extensively in the results, we focused on the notch pathway and particularly on DNER, a putative notch ligand, and PTPζ, a receptor phosphatase that controls DNER trafficking. Immunohistochemistry confirmed that both proteins are expressed more strongly in hair cells at the cochlear apex than in those at the base. At the apical surface of each hair cell, the proteins display polarized, mutually exclusive localization patterns. Using morpholinos to decrease the expression of DNER or PTPζ as well as a retroviral vector to overexpress DNER, we observed disturbances of hair-bundle morphology and orientation. Our results suggest a role for DNER and PTPζ in hair-cell development and possibly in the specification of tonotopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.