ArticleCurrent biology : CB2011
Glial cells physiologically modulate clock neurons and circadian behavior in a calcium-dependent manner.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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92 citing papers in PubMed, 141 citations in OpenAlex.
- Peroxisomal import is circadian in glia and regulates sleep and lipid metabolism.PLoS biology · 2026Article
- Regulation of Metabolic Rhythms by Glial Clocks.Journal of biological rhythms · 2026Article
- Neurons and Glia Exhibit Distinct Age-Associated MitoTimer-Based Mitochondrial Dynamics in themicroPublication biology · 2026Article
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- Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies.Neurobiology of sleep and circadian rhythms · 2025Article
- Review
- Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024Review
- Single-cell transcriptomics reveals that glial cells integrate homeostatic and circadian processes to drive sleep-wake cycles.Nature neuroscience · 2024Article
- Drosophila mutants lacking the glial neurotransmitter-modifying enzyme Ebony exhibit low neurotransmitter levels and altered behavior.Scientific reports · 2023Article
- Article
- Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Glia-Neurons Cross-Talk Regulated Through Autophagy.Frontiers in physiology · 2022Article
- Article
- Effects of insemination and blood-feeding on locomotor activity of wild-derived females of the malaria mosquito Anopheles coluzzii.Parasites & vectors · 2021Article
- Post-transcriptional modulators and mediators of the circadian clock.Chronobiology international · 2021Review
- Circadian regulation of the Drosophila astrocyte transcriptome.PLoS genetics · 2021Article
- Tyramine synthesis, vesicular packaging, and the SNARE complex function coordinately in astrocytes to regulate Drosophila alcohol sedation.Addiction biology · 2021Article
- Identification of Genes Contributing to a Long Circadian Period inJournal of biological rhythms · 2021Article
- Astrocyte Clocks and Glucose Homeostasis.Frontiers in endocrinology · 2021Review
32 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
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Abstract
backgroundAn important goal of contemporary neuroscience research is to define the neural circuits and synaptic interactions that mediate behavior. In both mammals and Drosophila, the neuronal circuitry controlling circadian behavior has been the subject of intensive investigation, but roles for glial cells in the networks controlling rhythmic behavior have only begun to be defined in recent studies.
resultsHere, we show that conditional, glial-specific genetic manipulations affecting membrane (vesicle) trafficking, the membrane ionic gradient, or calcium signaling lead to circadian arrhythmicity in adult behaving Drosophila. Correlated and reversible effects on a clock neuron peptide transmitter (PDF) and behavior demonstrate the capacity for glia-to-neuron signaling in the circadian circuitry. These studies also reveal the importance of a single type of glial cell-the astrocyte-and glial internal calcium stores in the regulation of circadian rhythms.
conclusionsThis is the first demonstration in any system that adult glial cells can physiologically modulate circadian neuronal circuitry and behavior. A role for astrocytes and glial calcium signaling in the regulation of Drosophila circadian rhythms emphasizes the conservation of cellular and molecular mechanisms that regulate behavior in mammals and insects.
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