ReviewCurrent opinion in structural biology2011
Metagenomics and the protein universe.
Review in Current opinion in structural biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Small Disulfide Proteins with Antifungal Impact: NMR Experimental Structures as Compared to Models of Alphafold Versions.International journal of molecular sciences · 2025Article
- The Impact of Metagenomics on Biocatalysis.Angewandte Chemie (International ed. in English) · 2024Review
- Thermophilic Carboxylesterases from Hydrothermal Vents of the Volcanic Island of Ischia Active on Synthetic and Biobased Polymers and Mycotoxins.Applied and environmental microbiology · 2023Article
- A structural biology community assessment of AlphaFold2 applications.Nature structural & molecular biology · 2022Article
- Toward a genetic system in the marine cyanobacteriumAccess microbiology · 2020Article
- Prediction of Enzyme Function Based on Three Parallel Deep CNN and Amino Acid Mutation.International journal of molecular sciences · 2019Article
- Unique function words characterize genomic proteins.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Applications of sequence coevolution in membrane protein biochemistry.Biochimica et biophysica acta. Biomembranes · 2018Review
- Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families.Scientific reports · 2017Article
- Exploring the dark foldable proteome by considering hydrophobic amino acids topology.Scientific reports · 2017Article
- Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering.Scientific reports · 2016Article
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- An assessment of the amount of untapped fold level novelty in under-sampled areas of the tree of life.Scientific reports · 2015Article
- A combined bioinformatics and functional metagenomics approach to discovering lipolytic biocatalysts.Frontiers in microbiology · 2015Article
- Remote homology and the functions of metagenomic dark matter.Frontiers in genetics · 2015Article
- Biophysics of protein evolution and evolutionary protein biophysics.Journal of the Royal Society, Interface · 2014Article
- Metagenomics reveals that detoxification systems are underrepresented in marine bacterial communities.BMC genomics · 2014Article
- An introduction to the analysis of shotgun metagenomic data.Frontiers in plant science · 2014Review
- A plasmid toolkit for cloning chimeric cDNAs encoding customized fusion proteins into any Gateway destination expression vector.BMC molecular biology · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Metagenomics sequencing projects have dramatically increased our knowledge of the protein universe and provided over one-half of currently known protein sequences; they have also introduced a much broader phylogenetic diversity into the protein databases. The full analysis of metagenomic datasets is only beginning, but it has already led to the discovery of thousands of new protein families, likely representing novel functions specific to given environments. At the same time, a deeper analysis of such novel families, including experimental structure determination of some representatives, suggests that most of them represent distant homologs of already characterized protein families, and thus most of the protein diversity present in the new environments are due to functional divergence of the known protein families rather than the emergence of new ones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.