ArticleCell2011
Thermal robustness of signaling in bacterial chemotaxis.
Article in Cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Enabling molecular signaling with temperature and ionic-strength independence or programmable dependence.Nature communications · 2026Article
- Spontaneous switching in a protein signalling array reveals near-critical cooperativity.Nature physics · 2026Article
- Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy.Drug design, development and therapy · 2025Review
- Dependence of diffusion ineLife · 2022Article
- Multiple functions of flagellar motility and chemotaxis in bacterial physiology.FEMS microbiology reviews · 2021Review
- Non-Genetic Diversity in Chemosensing and Chemotactic Behavior.International journal of molecular sciences · 2021Review
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- Aggregation Temperature of Escherichia coli Depends on Steepness of the Thermal Gradient.Biophysical journal · 2020Article
- Maximal information transmission is compatible with ultrasensitive biological pathways.Scientific reports · 2019Article
- Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis.Annual review of biophysics · 2018Review
- Phenotypic diversity and temporal variability in a bacterial signaling network revealed by single-cell FRET.eLife · 2017Article
- Article
- Dynamic domain arrangement of CheA-CheY complex regulates bacterial thermotaxis, as revealed by NMR.Scientific reports · 2017Article
- Optogenetic Manipulation of Cyclic Di-GMP (c-di-GMP) Levels Reveals the Role of c-di-GMP in Regulating Aerotaxis Receptor Activity in Azospirillum brasilense.Journal of bacteriology · 2017Article
- Mechanism of bidirectional thermotaxis ineLife · 2017Article
- Evolutionary Remodeling of Bacterial Motility Checkpoint Control.Cell reports · 2017Article
- Robust network topologies for generating oscillations with temperature-independent periods.PloS one · 2017Article
- Polar Localization of the Serine Chemoreceptor of Escherichia coli Is Nucleoid Exclusion-Dependent.Biophysical journal · 2016Article
- Conditions that Stabilize Membrane Domains Also Antagonize n-Alcohol Anesthesia.Biophysical journal · 2016Article
- Bacterial protein networks: properties and functions.Nature reviews. Microbiology · 2015Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Temperature is a global factor that affects the performance of all intracellular networks. Robustness against temperature variations is thus expected to be an essential network property, particularly in organisms without inherent temperature control. Here, we combine experimental analyses with computational modeling to investigate thermal robustness of signaling in chemotaxis of Escherichia coli, a relatively simple and well-established model for systems biology. We show that steady-state and kinetic pathway parameters that are essential for chemotactic performance are indeed temperature-compensated in the entire physiological range. Thermal robustness of steady-state pathway output is ensured at several levels by mutual compensation of temperature effects on activities of individual pathway components. Moreover, the effect of temperature on adaptation kinetics is counterbalanced by preprogrammed temperature dependence of enzyme synthesis and stability to achieve nearly optimal performance at the growth temperature. Similar compensatory mechanisms are expected to ensure thermal robustness in other systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.