Evidence map›Paper›PMID 21496313›Full record

ArticleBMC medical research methodology2011

Estimating uncertainty of alcohol-attributable fractions for infectious and chronic diseases.

Gerrit Gmel, Kevin D Shield, Hannah Frick, Tara Kehoe, Gerhard Gmel, Jürgen Rehm

Abstract read
In one paragraph

Article in BMC medical research methodology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. Burden of disease associated with alcohol use disorders in the United States.Alcoholism, clinical and experimental research · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gerrit GmelCentre for Addiction and Mental Health (CAMH) 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada. gerrit.gmel@gmail.com
Kevin D Shield
Hannah Frick
Tara Kehoe
Gerhard Gmel
Jürgen Rehm

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlcohol is a major risk factor for burden of disease and injuries globally. This paper presents a systematic method to compute the 95% confidence intervals of alcohol-attributable fractions (AAFs) with exposure and risk relations stemming from different sources.

methodsThe computation was based on previous work done on modelling drinking prevalence using the gamma distribution and the inherent properties of this distribution. The Monte Carlo approach was applied to derive the variance for each AAF by generating random sets of all the parameters. A large number of random samples were thus created for each AAF to estimate variances. The derivation of the distributions of the different parameters is presented as well as sensitivity analyses which give an estimation of the number of samples required to determine the variance with predetermined precision, and to determine which parameter had the most impact on the variance of the AAFs.

resultsThe analysis of the five Asian regions showed that 150 000 samples gave a sufficiently accurate estimation of the 95% confidence intervals for each disease. The relative risk functions accounted for most of the variance in the majority of cases.

conclusionsWithin reasonable computation time, the method yielded very accurate values for variances of AAFs.

Indexed as

Monte Carlo MethodAge FactorsAlcohol-Related DisordersChronic DiseaseCommunicable DiseasesCost of IllnessHumansPrevalenceRisk Factors

Identifiers

PMID21496313
PMCPMC3088897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.