Evidence map›Paper›PMID 21496215›Full record

ArticleVirology journal2011

Hepatitis E virus infection in HIV-infected patients with elevated serum transaminases levels.

Pierre Sellier, Marie-Christine Mazeron, Sophie Tesse, Esma Badsi, John Evans, Jean-Dominique Magnier, Marie-Jose Sanson-Le-Pors, Jean-François Bergmann, Elisabeth Nicand

Open access · goldAbstract read
In one paragraph

Article in Virology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Hepatitis E Infection in HIV-Infected Patients.Frontiers in microbiology · 2019
    Article
  7. Article
  8. No molecular evidence of Hepatitis E infection among patients with HIV in Iran.Medical journal of the Islamic Republic of Iran · 2017
    Article
  9. Hepatitis E virus: An ancient hidden enemy in Latin America.World journal of gastroenterology · 2016
    Review
  10. Chronic hepatitis E: A brief review.World journal of hepatology · 2015
    Review
  11. Article
  12. Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014
    Article
  13. Article
  14. Hepatitis E virus infection.Clinical microbiology reviews · 2014
    Review
  15. Review
  16. Chronic hepatitis e virus infection and treatment.Journal of clinical and experimental hepatology · 2013
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pierre SellierUnite des Maladies Infectieuses et Tropicales, Service de Medecine Interne A, Hopital Lariboisiere, 2, rue Ambroise Pare, 75010, Paris, France. pierre.sellier@lrb.aphp.fr
Marie-Christine Mazeron
Sophie Tesse
Esma Badsi
John Evans
Jean-Dominique Magnier
Marie-Jose Sanson-Le-Pors
Jean-François Bergmann
Elisabeth Nicand
Hôpital Lariboisière · FRHIA du Val-de-Grâce à Paris · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increases in aminotransferases levels are frequently encountered in HIV-positive patients and often remain unexplained. The role in this setting and natural history of hepatitis E in HIV-infected patients are unknown. The aim of the study was to assess HEV infection in HIV-infected patients attending a Parisian hospital, with a current or previous cryptogenic hepatitis.191 plasma samples collected from 108 HIV-infected patients with elevated aminotransferases levels were retrospectively tested for the presence of hepatitis E virus (HEV) infection markers: anti-HEV IgM antibodies, anti-HEV IgG antibodies, anti-HEV IgG avidity index and plasma HEV RNA.One acute infection, documented by positive tests for anti-HEV IgM antibody, low anti-HEV IgG avidity index and plasma HEV RNA (genotype 3e), and three past infections were diagnosed, without any observed case of persistent infection. The acute hepatitis was benign and resolved spontaneously within two weeks. This infection was probably contracted locally. Acute HEV hepatitis can occur in HIV-infected patients but rarely explains cryptogenic hepatitis, at least in an urban HIV population, regardless geographic origin and CD4 counts.

Indexed as

AdultAntibody AffinityFemaleHepatitis AntibodiesHepatitis EHepatitis E virusHIV InfectionsHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedMolecular Sequence DataPakistanPrevalenceRetrospective StudiesHepatitis AntibodiesImmunoglobulin GImmunoglobulin MRNA, ViralTransaminases

Identifiers

PMID21496215
PMCPMC3104369
OpenAlexW2133274823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.