ArticleTransfusion2011
New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells.
Article in Transfusion, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review.Critical care (London, England) · 2013Pooled it
- The pro-inflammatory potential of microparticles in red blood cell units.Transfusion medicine (Oxford, England) · 2014Trial
- Article
- The Toxic Influence of Excess Free Iron on Red Blood Cells in the Biophysical Experiment: An In Vitro Study.Journal of toxicology · 2022Article
- Advances in nanomaterials for treatment of hypoxic tumor.National science review · 2021Article
- Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity.PloS one · 2021Article
- Restoration of Physiological Levels of Uric Acid and Ascorbic Acid Reroutes the Metabolism of Stored Red Blood Cells.Metabolites · 2020Article
- Peripartum Blood Transfusions are Associated with Increased Risk of Cancer: A National Retrospective Cohort Study.Clinical epidemiology · 2020Article
- Preclinical Evaluation of Safety and Biodistribution of Red Cell Microparticles: A Novel Hemostatic Agent.Journal of cardiovascular pharmacology and therapeutics · 2019Article
- Red blood cells: the forgotten player in hemostasis and thrombosis.Journal of thrombosis and haemostasis : JTH · 2019Review
- Fluid Management in Acute Respiratory Distress Syndrome.Seminars in respiratory and critical care medicine · 2019Review
- Effects of irradiation and leukoreduction on down-regulation of CXCL-8 and storage lesion in stored canine whole blood.Journal of veterinary science · 2019Article
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Effect of storage period of red blood cell suspensions on helper T-cell subpopulations.Blood transfusion = Trasfusione del sangue · 2018Article
- Leukoreduction of packed red blood cells attenuates proinflammatory properties of storage-derived microvesicles.The Journal of surgical research · 2018Article
- Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography.Scientific reports · 2017Article
- Biochemistry of malaria parasite infected red blood cells by X-ray microscopy.Scientific reports · 2017Article
- Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients.BioMed research international · 2017Observational
- Oncologic and surgical outcomes in colorectal cancer patients with liver cirrhosis: A propensity-matched study.PloS one · 2017Article
- Effectiveness of Provider Education Followed by Computerized Provider Order Entry Alerts in Reducing Inappropriate Red Blood Cell Transfusion.Journal of blood transfusion · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Red blood cell (RBC) transfusions are associated with inflammation and thrombosis, both arterial and venous, the mechanisms of which are not understood. Although a necessary life-saving procedure in modern medicine, transfusions have rarely been subjected to modern assessments of efficacy and safety, including randomized trials. Storage of RBCs induces changes, including the release of free hemoglobin and the accumulation of biologically active soluble mediators and microparticles. These mediators likely play a direct role in the inflammatory and prothrombotic properties of RBC transfusions. Methods such as leukoreduction, washing of RBCs, and rejuvenation may improve the quality of RBC transfusions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.