ArticleTransfusion2011
Red blood cell age and potentiation of transfusion-related pathology in trauma patients.
Article in Transfusion, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Recommendations on RBC Transfusions in Critically Ill Children With Acute Respiratory Failure From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Guideline
- Impact of the age of stored blood on trauma patient mortality: a systematic review.Canadian journal of surgery. Journal canadien de chirurgie · 2015Pooled it
- Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review.Critical care (London, England) · 2013Pooled it
- Membrane attack complex generation increases as a function of time in stored blood.Transfusion medicine (Oxford, England) · 2014Trial
- SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression.Medical hypotheses · 2020Article
- Lipopolysaccharide-Induced Hemolysis Is Abolished by Inhibition of Thrombin Generation but Not Inhibition of Platelet Aggregation.Inflammation · 2019Article
- Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy.The Analyst · 2018Article
- Mechanisms of Hemolysis During Sepsis.Inflammation · 2018Review
- Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study.PLoS medicine · 2018Article
- Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation.Transfusion · 2017Article
- Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage.Blood transfusion = Trasfusione del sangue · 2017Article
- Lipopolysaccharide-induced hemolysis: Evidence for direct membrane interactions.Scientific reports · 2016Article
- Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements.Transfusion · 2015Article
- The Effect of Red Blood Cell Transfusion on Cerebral Autoregulation in Patients with Severe Traumatic Brain Injury.Neurocritical care · 2015Observational
- Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage.Free radical biology & medicine · 2015Article
- Molecular mechanisms of erythrocyte aging.Biological chemistry · 2015Review
- Peroxiredoxin-2 recycling is inhibited during erythrocyte storage.Antioxidants & redox signaling · 2015Article
- T-cell suppression by red blood cells is dependent on intact cells and is a consequence of blood bank processing.Transfusion · 2014Article
- Research opportunities in optimizing storage of red blood cell products.Transfusion · 2014Article
- The deleterious effect of red blood cell storage on microvascular response to transfusion.The journal of trauma and acute care surgery · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The specific negative clinical manifestations associated with the transfusion of stored red blood cells (RBCs) and the corresponding mechanisms responsible for such phenomena remain poorly defined. Our recent studies document that leukoreduced older RBC units potentiate transfusion-related toxicity in trauma patients. It is our hypothesis that the transfusion of relatively older blood impedes microvascular perfusion. The central mechanisms proposed to mediate this microcirculatory alteration include: 1) the loss of RBC-dependent control of nitric oxide-mediated homeostasis concerning vasodilation and 2) immune cell and complement activation. In this review, we outline the background for our hypothesis and detail our current investigations toward the understanding of this pathophysiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.