ArticleThe International journal of eating disorders2012
Challenges in conducting a multi-site randomized clinical trial comparing treatments for adolescent anorexia nervosa.
Article in The International journal of eating disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00610753 (Family Therapy in the Treatment of Adolescent Anorexia Nervosa), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Family Therapy in the Treatment of Adolescent Anorexia Nervosa
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Family therapy approaches for anorexia nervosa.The Cochrane database of systematic reviews · 2019Pooled it
- Family therapy approaches for anorexia nervosa.The Cochrane database of systematic reviews · 2018Pooled it
- The potential of technology-based psychological interventions for anorexia and bulimia nervosa: a systematic review and recommendations for future research.Journal of medical Internet research · 2015Pooled it
- Stepping into day treatment approach versus inpatient treatment for adults with anorexia nervosa: the DAISIES RCT.Health technology assessment (Winchester, England) · 2025Trial
- Feasibility Study Combining Art Therapy or Cognitive Remediation Therapy with Family-based Treatment for Adolescent Anorexia Nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2018Trial
- Can adaptive treatment improve outcomes in family-based therapy for adolescents with anorexia nervosa? Feasibility and treatment effects of a multi-site treatment study.Behaviour research and therapy · 2015Trial
- Development and evaluation of a treatment fidelity instrument for family-based treatment of adolescent anorexia nervosa.The International journal of eating disorders · 2015Trial
- Comparison of 2 family therapies for adolescent anorexia nervosa: a randomized parallel trial.JAMA psychiatry · 2014Trial
- Confronting fear using exposure and response prevention for anorexia nervosa: A randomized controlled pilot study.The International journal of eating disorders · 2014Trial
- The BMIgap tool to quantify transdiagnostic brain signatures of current and future weight.Nature. Mental health · 2025Article
- How feasible is nutrition intervention research in eating disorders? Lessons learnt from a pilot parallel randomised controlled trial of tyrosine supplementation in adolescents with anorexia nervosa.Journal of eating disorders · 2024Article
- Therapeutic Alliance in Web-Based Treatment for Eating Disorders: Secondary Analysis of a Randomized Controlled Trial.JMIR formative research · 2022Article
- "Include me if you can"-reasons for low enrollment of pediatric patients in a psychopharmacological trial.Trials · 2021Article
- Family-Based Treatment for Anorexia Nervosa Symptoms in High-Risk Youth: A Partially-Randomized Preference-Design Study.Frontiers in psychiatry · 2019Article
- The partial dopamine D2 receptor agonist aripiprazole is associated with weight gain in adolescent anorexia nervosa.The International journal of eating disorders · 2017Article
- A comprehensive review of psychodynamic treatments for eating disorders.Eating and weight disorders : EWD · 2016Review
- Cognitive Behavioral Therapy for Anorexia Nervosa: An Update.Current psychiatry reports · 2016Review
- Neurobiologically informed treatment for adults with anorexia nervosa: a novel approach to a chronic disorder.Dialogues in clinical neuroscience · 2015Article
- Psychopharmacologic treatment of eating disorders: emerging findings.Current psychiatry reports · 2015Review
- Time to restore body weight in adults and adolescents receiving cognitive behaviour therapy for anorexia nervosa.Journal of eating disorders · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo describe obstacles in the implementation of a controlled treatment trial of adolescent anorexia nervosa (AN).
methodThe original aim was to enter 240 participants with AN to one of four cells: Behavioral family therapy (BFT) plus fluoxetine; BFT plus placebo; systems family therapy (SFT) plus fluoxetine; SFT plus placebo.
resultsRecruitment was delayed pending a satisfactory resolution concerning participant safety. After 6 months of recruitment it became clear that the medication was associated with poor recruitment leading to a study redesign resulting in a comparison of two types of family therapy with a projected sample size of 160. One site was unable to recruit and was replaced. DISCUSSION: Problems with the delineation of safety procedures, recruitment, re-design of the study, and replacement of a site, were the main elements resulting in a 1-year delay. Suggestions are made for overcoming such problems in future AN trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.