Evidence map›Paper›PMID 21495033›Full record

ReviewJournal of surgical oncology2011

The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery.

Boudewijn E Schaafsma, J Sven D Mieog, Merlijn Hutteman, Joost R van der Vorst, Peter J K Kuppen, Clemens W G M Löwik, John V Frangioni, Cornelis J H van de Velde, Alexander L Vahrmeijer

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of surgical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 391 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
391citing papers in PubMed, 8 pooled it
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01738217 phase1 / phase2completednot on this mapstarted 2013, after this paper: background citation

Evaluation, for Patients Requiring a Liver Cancer Surgery, of the Use of Fluorescence Imaging Device: Faisability and Efficiency of Lesional and/or Anatomical Marking

TypeinterventionalSponsorCentre Leon BerardRan2013 to 2015Enrolled48ConditionsLiver NeoplasmsArmsFluobeam
NCT01926743 nacompletednot on this mapstarted 2013, after this paper: background citation

Identification of Complete Lymph Node Removal by Application of Near Infrared Fluorescence Imaging in Laparoscopic and Robotic Gastrectomy

TypeinterventionalSponsorYonsei UniversityRan2013 to 2014Enrolled40ConditionsGastric CancerArmsNear infrared fluorescence imaging during laparoscopic or robotic gastrectomy
NCT02820467 phase3unknown statusnot on this mapstarted 2015, after this paper: background citation

Study of Parameters of Infracyanine Angiography as Diagnostic Tool of Critical Limb Ischemia

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2015 to 2017Enrolled30ConditionsPeripheral Arterial DiseaseArmsfluorescence angiography
3 · Its place in the literature

Who cites it

391 citing papers in PubMed, 8 syntheses or guidelines pooled it, 795 citations in OpenAlex.

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331 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Boudewijn E SchaafsmaDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
J Sven D Mieog
Merlijn Hutteman
Joost R van der Vorst
Peter J K Kuppen
Clemens W G M Löwik
John V Frangioni
Cornelis J H van de Velde
Alexander L Vahrmeijer
Leiden University Medical Center · NLBeth Israel Deaconess Medical Center · US

Funding

Intraoperative Near-Infrared Fluorescence ImagingR01CA115296 · NCI · CURADEL, LLC · PI FRANGIONI, JOHN V · 2005 to 2014
$13.9M
Objective Flap Assessment During Reconstructive SurgeryR01EB005805 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FRANGIONI, JOHN V · 2006 to 2009
$1.5M
NCI NIH HHS R01 CA115296NCI NIH HHS R01-CA-115296NIBIB NIH HHS R01 EB005805NIBIB NIH HHS R01-EB-005805
6 · The paper itself

Abstract

Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery.

Indexed as

Coloring AgentsContrast MediaFluorescent DyesIndocyanine GreenSurgery, Computer-AssistedHumansNeoplasmsColoring AgentsContrast MediaFluorescent DyesIndocyanine Green

Identifiers

PMID21495033
PMCPMC3144993
OpenAlexW1974100712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.