ArticleJournal of abnormal child psychology2011
Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence.
Article in Journal of abnormal child psychology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- CHRM2 Genotype Affects Inhibitory Control Mechanisms During Cognitive Flexibility.Molecular neurobiology · 2019Article
- Affiliation with substance-using peers: Examining gene-environment correlations among parent monitoring, polygenic risk, and children's impulsivity.Developmental psychobiology · 2017Article
- Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict.Development and psychopathology · 2016Article
- Measurement invariance of alcohol instruments with Hispanic youth.Addictive behaviors · 2015Article
- Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes.Pharmacogenomics · 2014Article
- The Association Between Peer and own Aggression is Moderated by theJournal of research on adolescence : the official journal of the Society for Research on Adolescence · 2014Article
- Alcoholism and liver disease in Mexico: genetic and environmental factors.World journal of gastroenterology · 2013Review
- Dimensionality and Genetic Correlates of Problem Behavior in Low-Income African American Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Evidence for shared heritable influences across domains of substance use suggests that some genetic variants influence broad risk for externalizing behaviors. Theories of externalizing psychopathology also suggest that genetic liability for substance use manifests as temperamental risk factors, particularly those related to behavioral disinhibition, during adolescence. The cholinergic muscarinic receptor 2 gene (CHRM2) is a promising candidate for studying genetic influences on broad-based risk for externalizing traits. This study examined a candidate CHRM2 polymorphism (rs1455858) in relation to substance use and personality measures of disinhibition in a sample of high-risk adolescents (n = 124). Bivariate analyses and structural equation modeling (SEM) evaluated associations of rs1455858 with measures of drug involvement (alcohol, tobacco and marijuana) and disinhibition (indexed by impulsivity and sensation seeking scores). Bivariate analyses showed significant associations of CHRM2 with several behavioral phenotypes. In SEM analyses CHRM2 related significantly to latent measures of substance use and disinhibition; additionally, disinhibition mediated the association of CHRM2 with substance use. These results suggest that CHRM2 variants are potentially relevant for adolescent substance use and that temperamental risk factors could contribute to these associations.
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