ArticleCellular oncology (Dordrecht, Netherlands)2011
Pharmacological inhibition of AKT sensitizes MCF-7 human breast cancer-initiating cells to radiation.
Article in Cellular oncology (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 16 citations in OpenAlex.
- A radiosensitizer, gallotannin-rich extract from Bouea macrophylla seeds, inhibits radiation-induced epithelial-mesenchymal transition in breast cancer cells.BMC complementary medicine and therapies · 2021Article
- Cancer stem cells and chemoresistance: The smartest survives the raid.Pharmacology & therapeutics · 2016Review
- Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?Molecular carcinogenesis · 2015Article
- Kinetics of MDR transport in tumor-initiating cells.PloS one · 2013Article
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Authors and funding
8 authors at 4 institutions in 1 country.
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Abstract
backgroundCaner-initiating cells (CICs or cancer stem cells) have been shown both experimentally and clinically to be resistant to radiation. The mechanism underlying radioresistance remains unclear.
methodsIn the present study, we screened 51 genes which are potentially important in mediating radioresistance of breast CICs.
resultsThe expression of AKT1 and AKT2 at protein and mRNA levels was dramatically increased among the screened genes by 8 Gy radiation treatment in MCF-7 mammosphere cells (predominantly CD24(-/low)/CD44(+) CICs), but not in the bulk population of MCF-7 cells (predominantly CD24(+)/CD44(+)). Using apoptosis and clonogenic survival assays, we found pharmacological inhibition of AKT with selective inhibitors of AKT sensitized MCF-7 mammosphere cells, but not MCF-7 monolayer cells to radiation.
conclusionThe present findings suggest that treatment with AKT inhibitors prior to ionizing radiation treatment may be a potential benefit to patients with breast cancer, in particular to eradiate breast CICs.
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