ArticlePloS one2011
Asthma prevalence associated with geographical latitude and regional insolation in the United States of America and Australia.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Association of humidity and precipitation with asthma: a systematic review and meta-analysis.Frontiers in allergy · 2024Pooled it
- Sun Exposure and Asthma Prevalence in Spanish Schoolchildren and Adolescents in the Global Asthma Network (GAN) Phase I Study: A Semi-Individual Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Impact of lifestyle factors on adult-onset asthma in genetically high-risk individuals.Journal of global health · 2025Article
- Comparison of Asthma Phenotypes in Severe Asthma Cohorts (SARP, U-BIOPRED, ProAR and COREA) From 4 Continents.Allergy, asthma & immunology research · 2024Article
- Vitamin D Level and Immune Modulation in Children with Recurrent Wheezing.Children (Basel, Switzerland) · 2024Article
- Pre- and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood.Biomedicines · 2022Review
- Intersections of Adverse Childhood Experiences, Race and Ethnicity and Asthma Outcomes: Findings from the Behavioral Risk Factor Surveillance System.International journal of environmental research and public health · 2020Article
- Trends and regional distribution of outpatient claims for asthma, 2009-2016, Germany.Bulletin of the World Health Organization · 2020Article
- Article
- Association between Sun Exposure, Vitamin D Intake, Serum Vitamin D Level, and Immunoglobulin G Level in Patients with Neuromyelitis Optica Spectrum Disorder.International journal of preventive medicine · 2018Article
- Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement.Nutrients · 2017Observational
- Prevalence and Occupational and Environmental Risk Factors of Self-Reported Asthma: Evidence from a Cross-Sectional Survey in Seven Chinese Cities.International journal of environmental research and public health · 2016Article
- Sun Exposure and Its Effects on Human Health: Mechanisms through Which Sun Exposure Could Reduce the Risk of Developing Obesity and Cardiometabolic Dysfunction.International journal of environmental research and public health · 2016Review
- Vitamin D and the Development of Atopic Eczema.Journal of clinical medicine · 2015Review
- Sparse modeling of spatial environmental variables associated with asthma.Journal of biomedical informatics · 2015Article
- "Attacks" or "Whistling": Impact of Questionnaire Wording on Wheeze Prevalence Estimates.PloS one · 2015Article
- Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies.BMC pediatrics · 2014Article
- Vitamin D regulating TGF-β induced epithelial-mesenchymal transition.Respiratory research · 2014Article
- Operational definitions of asthma in recent epidemiological studies are inconsistent.Clinical and translational allergy · 2014Review
- Vitamin D and immunity.F1000prime reports · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been proposed that vitamin D deficiency may be responsible for an increase in the prevalence of allergic diseases and asthma worldwide. Human ability to generate physiologically required quantities of vitamin D through sun exposure is decreasing with increasing geographical latitude.
objectivesConsidering that vitamin D deficiency is usually due to lack of outdoor sun exposure, this study is designed to test the hypothesis that a higher prevalence of asthma should be expected at high relative to low geographical latitudes.
methodsLinear regression analyses are performed on asthma prevalence in the U.S. adult population vs. geographical latitude, insolation, air temperature, and air pollution (PM(2.5)) for 97 major metropolitan/micropolitan statistical areas of the continental United States of America and on general population asthma prevalence vs. geographical latitude in eight metropolitan areas of Australia.
resultsA 10° change in geographical latitude from southern to northern regions of the Eastern Seaboard is associated with a 2% increase in adult asthma prevalence (p<0.001). Total insolation in winter months is almost as strong as latitude in its ability to explain the observed spatial variation in the prevalence of asthma (r(2) = 0.43; p<0.001). Similar results are obtained using the Australian data (r(2) = 0.73; p<0.01), suggesting a consistent association between the latitude/insolation and asthma prevalence worldwide.
conclusionsThe results of this study suggest that, as a known modulator of the immune response closely linked with the geographical latitude and erythemal UV irradiation, vitamin D may play an important role in the development/exacerbation of asthma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.