ArticlePloS one2011
Drosophila TIEG is a modulator of different signalling pathways involved in wing patterning and cell proliferation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Krüppel-like factors family in health and disease.MedComm · 2024Review
- A novel insertional allele of theFrontiers in genetics · 2024Article
- The genetic basis of wing spots in Pieris canidia butterflies.BMC genomics · 2023Article
- Aryl hydrocarbon receptor and Krüppel like factor 10 mediate a transcriptional axis modulating immune homeostasis in mosquitoes.Scientific reports · 2022Article
- Metabolic gene regulation by Drosophila GATA transcription factor Grain.PLoS genetics · 2021Article
- A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Regulation of Carbohydrate Energy Metabolism inGenetics · 2017Review
- TIEG1 modulates β-catenin sub-cellular localization and enhances Wnt signaling in bone.Nucleic acids research · 2017Article
- KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes.Genome biology and evolution · 2015Article
- Article
- Hunting complex differential gene interaction patterns across molecular contexts.Nucleic acids research · 2014Article
- Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila.PLoS genetics · 2013Article
- Article
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Acquisition of a final shape and size during organ development requires a regulated program of growth and patterning controlled by a complex genetic network of signalling molecules that must be coordinated to provide positional information to each cell within the corresponding organ or tissue. The mechanism by which all these signals are coordinated to yield a final response is not well understood. Here, I have characterized the Drosophila ortholog of the human TGF-β Inducible Early Gene 1 (dTIEG). TIEG are zinc-finger proteins that belong to the Krüppel-like factor (KLF) family and were initially identified in human osteoblasts and pancreatic tumor cells for the ability to enhance TGF-β response. Using the developing wing of Drosophila as "in vivo" model, the dTIEG function has been studied in the control of cell proliferation and patterning. These results show that dTIEG can modulate Dpp signalling. Furthermore, dTIEG also regulates the activity of JAK/STAT pathway suggesting a conserved role of TIEG proteins as positive regulators of TGF-β signalling and as mediators of the crosstalk between signalling pathways acting in a same cellular context.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.