Conservative management of Candida infection of prosthetic aortic graft by means of caspofungin and fluconazole alone.

Lukas J Motloch, Dennis Rottlaender, Turak Darabi, Insa Joost, Erland Erdmann, Uta C Hoppe

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In one paragraph

Article in Texas Heart Institute journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.9field-weighted citation impact, top 25% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

Outcomes of Candida and Non-Candida Aortic Graft Infection.Vascular and endovascular surgery · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lukas J MotlochDepartment of Internal Medicine III, University of Cologne, 50937 Cologne, Germany. lukas.motloch@uk-koeln.de

Dennis Rottlaender

Turak Darabi

Insa Joost

Erland Erdmann

Uta C Hoppe

University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candida albicans infections after prosthetic graft implantation due to acute aortic dissection are rare. A combination of surgical resection and lifelong antifungal drug therapy is the gold standard for treatment of aortic graft infection, yet surgical interventions are associated with high mortality rates. Herein, we present the case of a 57-year-old man who presented with peripheral microembolism due to late-onset C. albicans infection of a prosthetic graft of the thoracic aorta, which was diagnosed by positron emission tomographic imaging. Given the high risk of reoperation, the patient was treated with intravenous caspofungin for 4 weeks, followed by oral administration of fluconazole. During a follow-up of 500 days, he remained asymptomatic, with slightly elevated inflammatory markers. This case suggests that in some instances, particularly in patients with high operative risk, Candida prosthetic graft infection can be managed conservatively with antifungal therapy alone. However, such an approach should be applied with caution and necessitates close follow-up on a long-term basis.

Indexed as

Antifungal AgentsAorta, ThoracicAortographyBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCandidiasisCaspofunginDrug Administration ScheduleDrug Therapy, CombinationEchinocandinsEchocardiography, TransesophagealEmbolismFluconazoleHumansLipopeptidesMagnetic Resonance AngiographyAntifungal AgentsCaspofunginEchinocandinsFluconazoleLipopeptidesAneurysm, dissectingantifungal agents/administration & dosage/therapeutic useaorta, thoracicaortic diseases/therapyCandida albicans/drug effectscandidiasiscaspofungin/administration & dosagefluconazole/administration & dosagemicroembolismpositron-emission tomographypostoperative complicationsprosthesis-related infections/drug therapy/radiography

Identifiers

PMID21494537

PMCPMC3066806

OpenAlexW159212093

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.