ArticleMacromolecules2009
Gelation of Covalently Cross-Linked PEG-Heparin Hydrogels.
Article in Macromolecules, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Design and Characterization of Thioester Networks with Adaptable and Enzymatically Degradable Cross-Links.Macromolecules · 2025Article
- Cell-Material Interactions in Covalent Adaptable Thioester Hydrogels.ACS biomaterials science & engineering · 2024Article
- Nanoparticle transport in biomimetic polymer-linked emulsions.AIChE journal. American Institute of Chemical Engineers · 2024Article
- Characterizing rheological properties and microstructure of thioester networks during degradation.Soft matter · 2023Article
- Characterizing Phase Transitions of Microfibrillated Cellulose Induced by Anionic and Cationic Surfactants.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Molecular Weight Distribution of Branched Polymers: Comparison between Monte Carlo Simulation and Flory-Stockmayer Theory.Polymers · 2023Article
- Gelation phase diagrams of colloidal rod systems measured over a large composition space.RSC advances · 2022Article
- (Macro)molecular self-assembly for hydrogel drug delivery.Advanced drug delivery reviews · 2021Review
- Determining How Human Mesenchymal Stem Cells Change Their Degradation Strategy in Response to Microenvironmental Stiffness.Biomacromolecules · 2020Article
- Microrheological characterization of covalent adaptable hydrogels for applications in oral delivery.Soft matter · 2019Article
- Triggered disassembly and reassembly of actin networks induces rigidity phase transitions.Soft matter · 2019Article
- Structural Changes in Polymeric Gel Scaffolds Around the Overlap Concentration.Frontiers in chemistry · 2019Article
- Dynamic Light Scattering Microrheology Reveals Multiscale Viscoelasticity of Polymer Gels and Precious Biological Materials.ACS central science · 2017Article
- Evolution of mechanics in α-helical peptide conjugated linear- and star-block PEG.Soft matter · 2017Article
- Rheological and Mechanical Behavior of Silk Fibroin Reinforced Waterborne Polyurethane.Polymers · 2016Article
- Designing degradable hydrogels for orthogonal control of cell microenvironments.Chemical Society reviews · 2013Review
- Article
- Optimal poly(L-lysine) grafting density in hydrogels for promoting neural progenitor cell functions.Biomacromolecules · 2012Article
- Differential effects of substrate modulus on human vascular endothelial, smooth muscle, and fibroblastic cells.Journal of biomedical materials research. Part A · 2012Article
- Lubricated biodegradable polymer networks for regulating nerve cell behavior and fabricating nerve conduits with a compositional gradient.Biomacromolecules · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We study PEG-heparin hydrogels to identify compositions that lead to gel formation and measure the corresponding gelation kinetics. The material consists of a maleimide-functionalized high molecular weight heparin (HMWH) backbone covalently cross-linked with bis-thiol poly(ethylene glycol) (PEG). Using multiple particle tracking microrheology, we investigate a broad composition space, defined by the number of maleimide functional sites per HMWH (f = 3.9-11.8), the molecular weight of the PEG cross-linker (M(n) = 2000, 5000, and 10 000), and the concentrations of the heparin and PEG polymers. Gelation kinetics are characterized by time-cure superposition, yielding the gel time, t(c), and the critical relaxation exponent, n. Gelation times range from 5 < t(c) ≤ 45 min, with the fastest kinetics occurring for the highest HMWH maleimide functionalities. t(c) depends nonmonotonically on the PEG cross-linker molecular weight, suggesting that gelation is affected by the length of the cross-linker relative to intermolecular interactions between heparin molecules. The critical relaxation exponent decreases from n = 0.52 for PEG 2000 to n = 0.39 for PEG 10 000. Finally, 219 equilibrated samples taken over the entire composition space are identified as liquid or solid, defining the "gelation envelope". The boundaries of this empirical gelation envelope are in good agreement with Flory-Stockmayer theory. In all, microrheological measurements enable characterization over a large parameter space and provide crucial insight into the gelation of complex, multifunctional hydrogelators used in therapeutic applications.
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Registered trials
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