Evidence map›Paper›PMID 21494278›Full record

ReviewNature reviews. Microbiology2011

Herpesviruses remodel host membranes for virus egress.

David C Johnson, Joel D Baines

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 326 papers.

0numbers the graph read from it
0cells of the map it votes in
326citing papers in PubMed
25.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

326 citing papers in PubMed, 453 citations in OpenAlex.

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266 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David C JohnsonMolecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon 97219, USA.
Joel D Baines
York University · US

Funding

Herpes simplex virus egress from neurons into axons mediated by HSV membrane proteins gE/gI and US9 and axonal transport by kinesin motors.R01EY018755 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JOHNSON, DAVID C. · 2008 to 2023
$5.8M
Human cytomegalovirus entry into epithelial and endothelial cellsR01AI081517 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI JOHNSON, DAVID C. · 2009 to 2019
$4.6M
Nucleocapsid Envelopment Herpes Simplex Virus-1R01AI052341 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI BAINES, JOEL D. · 2003 to 2013
$3.6M
HERPES SIMPLEX VIRUS TERMINASESR01GM050740 · NIGMS · CORNELL UNIVERSITY ITHACA · PI BAINES, JOEL D. · 1995 to 2007
$2.3M
NEI NIH HHS R01 EY018755NIAID NIH HHS R01 AI081517NIAID NIH HHS R01 AI52341NIGMS NIH HHS R01 GM50740
6 · The paper itself

Abstract

Herpesviruses replicate their DNA and package this DNA into capsids in the nucleus. These capsids then face substantial obstacles to their release from cells. Unlike other DNA viruses, herpesviruses do not depend on disruption of nuclear and cytoplasmic membranes for their release. Enveloped particles are formed by budding through inner nuclear membranes, and then these perinuclear enveloped particles fuse with outer nuclear membranes. Unenveloped capsids in the cytoplasm are decorated with tegument proteins and then undergo secondary envelopment by budding into trans-Golgi network membranes, producing infectious particles that are released. In this Review, we describe the remodelling of host membranes that facilitates herpesvirus egress.

Indexed as

Virus ReleaseAnimalsCell MembraneEpithelial CellsHerpesviridaeHerpesviridae InfectionsHumans

Identifiers

PMID21494278
OpenAlexW2021304970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.