ArticleJournal of the American Society of Nephrology : JASN2011
Statin use associates with a lower incidence of acute kidney injury after major elective surgery.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Fenoldopam for preventing and treating acute kidney injury.The Cochrane database of systematic reviews · 2024Pooled it
- Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery.The Cochrane database of systematic reviews · 2013 · on this mapPooled it
- Statin exposure after multiple myeloma diagnosis and risk of all-cause mortality, venous thromboembolism, pathological fractures, and acute kidney injury: a propensity score-matched retrospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Divergent Role of Statin Use and Intensity in Patients Undergoing Transcatheter Aortic Valve Replacement.Cardiorenal medicine · 2026Article
- Effect of statins and antihyperglycemics on chronic kidney disease in patients with type 2 diabetes mellitus: a retrospective cohort study with a 12-year follow-up.Journal of pharmaceutical policy and practice · 2025Article
- The association of statin use with in-hospital mortality in patients with acute kidney injury during hospitalization: A retrospective analysis.Nephrology (Carlton, Vic.) · 2024Article
- Statin use in total joint arthroplasty: a systematic review.Annals of medicine and surgery (2012) · 2024Article
- Genetic variations in HMGCR and PCSK9 and kidney function: a Mendelian randomization study.Kidney research and clinical practice · 2023Article
- Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1.EMBO reports · 2023Article
- Effects of statins on the incidence and outcomes of acute kidney injury in critically ill patients: a systematic review and meta-analysis.Archives of medical science : AMS · 2023Review
- Effect of lipid-lowering medications in patients with coronary artery bypass grafting surgery outcomes.BMC anesthesiology · 2022Article
- A web-based machine-learning algorithm predicting postoperative acute kidney injury after total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Association of Prior to Intensive Care Unit Statin Use With Outcomes on Patients With Acute Kidney Injury.Frontiers in medicine · 2021Article
- Analysis of Risk Factors for Perioperative Acute Kidney Injury and Management Strategies.Frontiers in medicine · 2021Review
- Interhospital Transfer and Outcomes in Patients with AKI: A Population-Based Cohort Study.Kidney360 · 2020Article
- Management of Acute Kidney Injury Following Major Abdominal Surgery: A Contemporary Review.Journal of clinical medicine · 2020Review
- Statin use and the risk of acute kidney injury in older adults.BMC nephrology · 2019Article
- Preadmission Statin Therapy Is Associated with a Lower Incidence of Acute Kidney Injury in Critically Ill Patients: A Retrospective Observational Study.Journal of clinical medicine · 2018Article
- Perioperative Statin Use and Acute Kidney Injury in Patients Undergoing Partial Nephrectomy.Kidney cancer (Clifton, Va.) · 2018Article
- Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2017Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Statins abrogate ischemic renal injury in animal studies but whether they are renoprotective in humans is unknown. We conducted a population-based retrospective cohort study that included 213,347 older patients who underwent major elective surgery in the province of Ontario, Canada from 1995 to 2008. During the first 14 postoperative days, 1.9% (4020 patients), developed acute kidney injury and 0.5% (1173 patients), required acute dialysis. The 30-day mortality rate was 2.8% (5974 patients). Prior to surgery, 32% of patients were taking a statin. After statistical adjustment for patient and surgical characteristics, statin use associated with 16% lower odds of acute kidney injury (OR, 0.84; 95% CI, 0.79 to 0.90), 17% lower odds of acute dialysis (OR, 0.83; 95% CI, 0.72 to 0.95), and 21% lower odds of mortality (OR, 0.79; 95% CI, 0.74 to 0.85). Propensity score matching produced similar results. These data suggest that statins may protect against renal complications after major elective surgery and reduce perioperative mortality.
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