ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Chronic continuous positive airway pressure (CPAP) reduces airway reactivity in vivo in an allergen-induced rabbit model of asthma.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03154762 (National Institute of Respiratory Diseases Mexico), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
National Institute of Respiratory Diseases Mexico
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- A randomized trial of continuous positive airway pressure for the asthma of obesity.Respiratory research · 2025Trial
- Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma: a randomized crossover trial.World journal of pediatrics : WJP · 2021Trial
- Effect of Continuous Positive Airway Pressure on Airway Reactivity in Asthma. A Randomized, Sham-controlled Clinical Trial.Annals of the American Thoracic Society · 2016Trial
- Use of continuous positive airway pressure reduces airway reactivity in adults with asthma.The European respiratory journal · 2013Trial
- Extending CPAP in stable preterm infants to increase lung growth and development as measured by pulmonary function testing.Seminars in perinatology · 2025Review
- CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3.Pediatric research · 2022Article
- Continuous Positive Airway Pressure (CPAP) in Non-Apneic Asthma: A Clinical Review of Current Evidence.Turkish thoracic journal · 2020Review
- Effect of CPAP on airway reactivity and airway inflammation in children with moderate-severe asthma.Respirology (Carlton, Vic.) · 2019Article
- Molecular Mechanisms for the Mechanical Modulation of Airway Responsiveness.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Modulation of protective reflex cough by acute immune driven inflammation of lower airways in anesthetized rabbits.PloS one · 2019Article
- Prestretched airway smooth muscle response to length oscillation.Physiological reports · 2017Article
- Increased airway reactivity in a neonatal mouse model of continuous positive airway pressure.Pediatric research · 2015Article
- Evaluation of functional, autonomic and inflammatory outcomes in children with asthma.World journal of clinical cases · 2015Review
- Obesity in asthma: approaches to treatment.Current allergy and asthma reports · 2013Review
- Increased mechanical strain imposed on murine lungs during ventilation in vivo depresses airway responsiveness and activation of protein kinase Akt.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Airway smooth muscle in the pathophysiology and treatment of asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Review
- The effect of lung stretch during sleep on airway mechanics in overweight and obese asthma.Respiratory physiology & neurobiology · 2013Article
- Therapeutic options for severe asthma.Archives of medical science : AMS · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have demonstrated that chronic mechanical strain produced by continuous positive airway pressure (CPAP) reduces in vivo airway reactivity in rabbits and ferrets. For CPAP to potentially have a therapeutic benefit for asthmatic subjects, the reduction in airway responsiveness would need to persist for 12-24 h after its discontinuation, require application for only part of the day, and be effective in the presence of atopic airway inflammation. In the present study, airway responsiveness to acetylcholine or methacholine was measured during mechanical ventilation following three different protocols in which active, nonanesthetized, tracheotomized rabbits were treated with High vs. Low CPAP (6 vs. 0 cmH(2)O). 1) High CPAP was applied continuously for 4 days followed by 1 day of Low CPAP; 2) High CPAP was applied at night and Low CPAP during the daytime for 4 days, and 3) High CPAP was applied for 4 days in animals following ovalbumin (Ova) sensitization and challenge. For all three protocols, treatment with High CPAP resulted in significantly reduced airway responsiveness compared with treatment with Low CPAP. Cumulatively, our in vivo results in rabbits suggest that high CPAP, even when applied only at night, produces a persistent reduction of airway responsiveness. In addition, CPAP reduces airway responsiveness even in the presence of atopic airway inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.