ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Elevated vertebrobasilar artery resistance in neonatal spontaneously hypertensive rats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Regional cerebral perfusion and sympathetic activation during exercise in hypoxia and hypercapnia: preliminary insight into 'Cushing's mechanism'.The Journal of physiology · 2025Article
- Cerebrovascular Variants and the Role of the Selfish Brain in Young-Onset Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Is the Brain an Early or Late Component of Essential Hypertension?American journal of hypertension · 2020Review
- Repaired coarctation of the aorta, persistent arterial hypertension and the selfish brain.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Article
- Inflammatory pathways are central to posterior cerebrovascular artery remodelling prior to the onset of congenital hypertension.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Cerebral AβJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Differences in autonomic innervation to the vertebrobasilar arteries in spontaneously hypertensive and Wistar rats.The Journal of physiology · 2018Article
- Review
- Abnormal oxygen homeostasis in the nucleus tractus solitarii of the spontaneously hypertensive rat.Experimental physiology · 2017Article
- Parasympathetic innervation of vertebrobasilar arteries: is this a potential clinical target?The Journal of physiology · 2016Review
- Immunohistochemical evidence of tissue hypoxia and astrogliosis in the rostral ventrolateral medulla of spontaneously hypertensive rats.Brain research · 2016Article
- Hypertension: a problem of organ blood flow supply-demand mismatch.Future cardiology · 2016Review
- Glia, sympathetic activity and cardiovascular disease.Experimental physiology · 2016Review
- Pacemaking Property of RVLM Presympathetic Neurons.Frontiers in physiology · 2016Review
- Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat.Hypertension (Dallas, Tex. : 1979) · 2015Article
- The sympathetic nervous system and blood pressure in humans: implications for hypertension.Journal of human hypertension · 2012Review
- Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?Current hypertension reports · 2012Review
- Moyamoya disease manifesting with bilateral involvement of the proximal vertebral arteries: A case report.Brain circulationArticle
- Wall-to-lumen ratio of intracranial arteries measured by indocyanine green angiography.Asian journal of neurosurgeryArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
There is a strong correlation between increased vertebral artery resistance and arterial blood pressure in humans. The reasons for this increased resistance at high systemic pressure remain unknown, but may include raised sympathetic activity. With the recent finding that prehypertensive spontaneously hypertensive (PHSH) rats, which have raised sympathetic nerve activity, but a blood pressure comparable to normotensive rat strains, we hypothesized that its vertebrobasilar vascular resistance would already be raised and, as a consequence, would exhibit a more responsive Cushing response (e.g., brain ischemia evoked sympathoexcitation and a pressor response). We report that PHSH rats exhibited a remodeling of the basilar artery (i.e., increased wall thickness and lower lumen-to-wall thickness ratio) that occurred before the onset of hypertension. In a novel in vitro vascularly isolated, arterially perfused brain stem preparation of PHSH rats of 4-5 wk of age, brain stem vascular resistance was raised by ∼35% relative to age- and sex-matched normotensive rats (P < 0.05). In the in situ arterial perfused working heart-brain stem preparation, occlusion of both vertebral arteries in the PHSH rat resulted in a significantly greater increase in sympathetic activity (57 vs. 20%, PHSH vs. control; P < 0.01) that triggered a greater increase in arterial perfusion pressure (8 vs. 3 mmHg, PHSH vs. control; P < 0.01) compared with normotensive rats. These data indicate raised vertebrobasilar artery resistance before the onset of hypertension in the PHSH rat. With the raised responsiveness of the Cushing response in the PHSH rat, we discuss the possibility of brain stem perfusion as a central nervous system determinant of the set point of vasomotor sympathetic tone in the hypertensive condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.