ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2011
Race as a social construct in head and neck cancer outcomes.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint.DNA repair · 2025Article
- Article
- MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.The Journal of clinical investigation · 2014Article
- Barriers to oral cancer screening: a focus group study of rural Black American adults.Psycho-oncology · 2013Article
- Molecular characterization of head and neck cancer: how close to personalized targeted therapy?Molecular diagnosis & therapy · 2012Article
- What are our AIMs? Interdisciplinary Perspectives on the Use of Ancestry Estimation in Disease Research.AJOB primary research · 2012Article
- Identifying the risk factors for late-stage head and neck cancer.Expert review of anticancer therapy · 2011Review
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Authors and funding
3 authors.
Funding
Abstract
objectiveThe authors examined ancestry informative markers (AIMs) to estimate the amount of population admixture and control for this heterogeneity for stage and survival in a primary head and neck squamous cell carcinoma (HNSCC) cohort. STUDY
designHistorical cohort study.
settingIntegrated health care system. SUBJECTS: The cohort comprised 358 patients with HNSCC who self-reported race as Caucasian American (CA), African American (AA), or other.
methodsDNA was interrogated for West African (WA) and European genetic background by genotyping AIMs. Associations of race (self-report or WA ancestry) with stage and survival were analyzed using logistic regression and Cox regression modeling. A subgroup analysis for diagnosis (late vs early stage) and survival (time to death) and WA ancestry was performed for self-reported AAs.
resultsThere were significant associations between stage and self-reported race (P = .04 [univariate]) and with cancer site (oropharynx: P = .014; hypopharynx: P = .026 [multivariate]). For prognosis, there were significant multivariate associations between stage (P = .002), age (>65 years, P < .001), and cancer site (hypopharynx: P < .001; oral cavity: P = .049), but self-reported race was not associated with overall survival. Interestingly, there was no association with degree of WA ancestry and stage or survival. In the subgroup analysis of genetic ancestry among self-reported AAs, cancer site remained an independent risk factor for stage (other site: P = .026) and survival (oropharynx: P = .036). Late stage persisted as an independent variable for poor survival (P = .032).
conclusionsStratification within AAs by WA ancestry revealed no correlation with stage or survival, suggesting that HNSCC outcomes with race may be owing to social/behavior factors rather than biological differences.
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