Evidence map›Paper›PMID 21493001›Full record

ReviewCancer letters2011

Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients.

Ethel Cesarman

Abstract readReview
In one paragraph

Review in Cancer letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 185 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Detection ofPathogens (Basel, Switzerland) · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Prevention of OncogenicTransplant international : official journal of the European Society for Organ Transplantation · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ethel CesarmanWeill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA. ecesarm@med.cornell.edu
Cornell University · US

Funding

University of Southern CaliforniaU01CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 2006 to 2014
$54.7M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
Survival Signals in AIDS LymphomasR01CA068939 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CESARMAN, ETHEL · 2001 to 2010
$2.6M
An infrastructure for cancer virus discovery from next-generation sequencing dataRC2CA148317 · NCI · DANA-FARBER CANCER INST · PI MEYERSON, MATTHEW L. · 2009 to 2010
$1.6M
NCI NIH HHS 3U01CA12194NCI NIH HHS R01 CA068939NCI NIH HHS R01-CA068939NCI NIH HHS RC2 CA148317NCI NIH HHS RC2CA148317NCI NIH HHS U01 CA121947NCRR NIH HHS UL1 RR024996
6 · The paper itself

Abstract

Two lymphotropic human gamma herpesviruses can cause lymphoproliferative disorders: Epstein Barr virus (EBV, formally designated as human herpesvirus 4) and Kaposi sarcoma herpesvirus (KSHV, also called human herpesvirus 8). Individuals with inherited or acquired immunodeficiency have a greatly increased risk of developing a malignancy caused by one of these two viruses. Specific types of lymphoproliferations, including malignant lymphomas, occur in individuals with HIV infection, transplant recipients and children with primary immunodeficiency. Some of these diseases, such as Hodgkin's and non-Hodgkin lymphoma resemble those occurring in immunocompetent patients, but the proportion of tumors in which EBV is present is increased. Others, like primary effusion lymphoma and polymorphic post-transplant lymphoproliferative disorder are rarely seen outside the context of a specific immunodeficient state. Understanding the specific viral associations in selected lymphoproliferative disorders, and the insights into the molecular mechanisms of viral oncogenesis, will lead to better treatments for these frequently devastating diseases.

Indexed as

Acquired Immunodeficiency SyndromeCastleman DiseaseCell Transformation, NeoplasticGammaherpesvirinaeHerpesviridae InfectionsHerpesvirus 4, HumanHerpesvirus 8, HumanHumansImmune SystemImmunocompromised HostLymphomaLymphoma, AIDS-RelatedLymphoproliferative DisordersModels, BiologicalVirus Latency

Identifiers

PMID21493001
PMCPMC3742547
OpenAlexW1994887878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.