ArticleSocial science & medicine (1982)2011
Social isolation, C-reactive protein, and coronary heart disease mortality among community-dwelling adults.
Article in Social science & medicine (1982), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- Effects of Objective and Perceived Social Isolation on Cardiovascular and Brain Health: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2022Pooled it
- Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis.Brain, behavior, and immunity · 2018Pooled it
- Social Isolation and Incidence of Chest Pain and Mortality in Older Adults of the United States Population: A Cross-Sectional Study From NHANES 2001-2018.Health science reports · 2026Article
- Latent profile analysis and determinants of social isolation among older adults in China.Frontiers in public health · 2026Article
- Social integration and mortality across the life course: findings from the Tromsø study.BMC public health · 2025Article
- Cumulative loneliness and memory function among U.S. older adults: the role of depressive symptoms.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Voluntary exercise is a moderately effective mitigator of chronic social isolation stress in two female rodent models.Physiology & behavior · 2025Article
- Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality.Nature human behaviour · 2025Article
- Dexmedetomidine's Effect on Catecholamine and Inflammation in Reducing In-Hospital Adverse Events for Older Patients with STEMI Undergoing Primary PCI.Drug design, development and therapy · 2025Article
- Housing insecurity pathways to physiological and epigenetic manifestations of health among aging adults: a conceptual model.Frontiers in public health · 2025Review
- Article
- Increases in Psychological Stress Are Associated With Higher Fasting Glucose in US Chinese Immigrants.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024Article
- Effects of Electroencephalogram Neurofeedback Intervention on Blood C-Reactive Protein Levels in Astronauts Attending 2-Week Long Analog Moon Mission.Brain sciences · 2024Article
- The pandemic and social experience: For whom did discrimination and social isolation increase?Cultural diversity & ethnic minority psychology · 2024Article
- Cardiometabolic Risk Increased in Working-Aged Adults During the COVID-19 Pandemic.Metabolic syndrome and related disorders · 2023Article
- Article
- Evaluation of Social Isolation Trajectories and Incident Cardiovascular Disease Among Middle-Aged and Older Adults in China: National Cohort Study.JMIR public health and surveillance · 2023Article
- Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity.International journal of molecular sciences · 2023Review
- Human social genomics: Concepts, mechanisms, and implications for health.Lifestyle medicine (Hoboken, N.J.) · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Social isolation confers increased risk for coronary heart disease (CHD) events and mortality. In two recent studies, low levels of social integration among older adults were related to higher levels of C-reactive protein (CRP), a marker of inflammation, suggesting a possible biological link between social isolation and CHD. The current study examined relationships among social isolation, CRP, and 15-year CHD death in a community sample of US adults aged 40 years and older without a prior history of myocardial infarction. A nested case-cohort study was conducted from a parent cohort of community-dwelling adults from the southeastern New England region of the United States (N = 2321) who were interviewed in 1989 and 1990. CRP levels were measured from stored sera provided by the nested case-cohort (n = 370), which included all cases of CHD death observed through 2005 (n = 48), and a random sample of non-cases. We found that the most socially isolated individuals had two-and-a-half times the odds of elevated CRP levels compared to the most socially integrated. In separate logistic regression models, both social isolation and CRP predicted later CHD death. The most socially isolated continued to have more than twice the odds of CHD death compared to the most socially integrated in a model adjusting for CRP and more traditional CHD risk factors. The current findings support social isolation as an independent risk factor of both high levels of CRP and CHD death in middle-aged adults without a prior history of myocardial infarction. Prospective study of inflammatory pathways related to social isolation and mortality are needed to fully delineate whether and how CRP or other inflammatory markers contribute to mechanisms linking social isolation to CVD health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.