ArticleCell division2011
Centriole assembly and the role of Mps1: defensible or dispensable?
Article in Cell division, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Review
- Role of E2Fs and mitotic regulators controlled by E2Fs in the epithelial to mesenchymal transition.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop.Proteins · 2019Article
- Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis.Open biology · 2018Review
- Protein kinase TTK promotes proliferation and migration and mediates epithelial-mesenchymal transition in human bladder cancer cells.International journal of clinical and experimental pathology · 2018Article
- Mps1 is SUMO-modified during the cell cycle.Oncotarget · 2016Article
- Article
- Denervation impairs regeneration of amputated zebrafish fins.BMC developmental biology · 2014Article
- Quantitative immunofluorescence assay to measure the variation in protein levels at centrosomes.Journal of visualized experiments : JoVE · 2014Article
- Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells.Cell division · 2014Article
- Characterization of novel MPS1 inhibitors with preclinical anticancer activity.Cell death and differentiation · 2013Article
- VDAC3 and Mps1 negatively regulate ciliogenesis.Cell cycle (Georgetown, Tex.) · 2013Article
- Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma.Oncogene · 2013Article
- Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer.Frontiers in oncology · 2013Review
- VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.Cell cycle (Georgetown, Tex.) · 2012Article
- The MPS1 family of protein kinases.Annual review of biochemistry · 2012Review
- Structural and functional characterization of the protein kinase Mps1 in Arabidopsis thaliana.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C. elegans being a notable exception, and has also been shown to regulate the spindle checkpoint and an increasing number of cellular functions relating to genomic stability. While its function in the spindle checkpoint appears to be both universally conserved and essential in most organisms, conservation of its originally described function in spindle pole duplication has proven controversial, and it is less clear whether Mps1 is essential for centrosome duplication outside of budding yeast. Recent studies of Mps1 have identified at least two distinct functions for Mps1 in centriole assembly, while simultaneously supporting the notion that Mps1 is dispensable for the process. However, the fact that at least one centrosomal substrate of Mps1 is conserved from yeast to humans down to the phosphorylation site, combined with evidence demonstrating the exquisite control exerted over centrosomal Mps1 levels suggest that the notion of being essential may not be the most important of distinctions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.