ArticleBMC neuroscience2011
MK801 attenuates secondary injury in a mouse experimental compression model of spinal cord trauma.
Article in BMC neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury.Neurospine · 2022Article
- Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling.Inflammopharmacology · 2019Article
- A Neuroprotective Effect of the Glutamate Receptor Antagonist MK801 on Long-Term Cognitive and Behavioral Outcomes Secondary to Experimental Cerebral Malaria.Molecular neurobiology · 2017Article
- Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke.Neural regeneration research · 2017Review
- Recent advances in the pharmacologic treatment of spinal cord injury.Metabolic brain disease · 2015Review
- N-methyl-D-aspartate receptor antagonist MK-801 prevents apoptosis in rats that have undergone fetal spinal cord transplantation following spinal hemisection.Experimental and therapeutic medicine · 2014Article
- Intra-Spinal Bone Marrow Mononuclear Cells Transplantation Inhibits the Expression of Nuclear Factor-κB in Acute Transection Spinal Cord Injury in Rats.Journal of Korean Neurosurgical Society · 2014Article
- Spinal NMDA receptor activation constrains inactivity-induced phrenic motor facilitation in Charles River Sprague-Dawley rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Curcumin protects against ischemic spinal cord injury: The pathway effect.Neural regeneration research · 2013Article
- NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.Neuroscience letters · 2013Article
- An update on spinal cord injury research.Neuroscience bulletin · 2013Review
- Effect of intra-cisternal application of kainic acid on the spinal cord and locomotor activity in rats.International journal of clinical and experimental pathology · 2013Article
- Gene expression profiling of liver X receptor α and Bcl-2-associated X protein in experimental transection spinal cord-injured rats.The journal of spinal cord medicine · 2013Article
- Article
- A non-opioid pathway for dynorphin-caused spinal cord injury in rats.Neural regeneration research · 2012Article
- Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment.Neural regeneration research · 2012Article
Corrections and comments
- Retraction · 2025-04-14Concerns/Issues about Data · Concerns/Issues about Image · Duplication of/in Image · Objections by Author(s) · Unreliable Data ·
- Retracted
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of spinal cord injury (SCI). The aim of this study was to investigate the neuroprotective effect of dizocilpine maleate, MK801 (2 mg/Kg, 30 min and 6 hours after injury) in a mice model of SCI. The spinal cord trauma was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy.
resultsSpinal cord injury in mice resulted in severe trauma characterized by edema, neutrophil infiltration and apoptosis. In this study we clearly demonstrated that administration of MK801 attenuated all inflammatory parameters. In fact 24 hours after injury, the degree of spinal cord inflammation and tissue injury (evaluated as histological score), infiltration of neutrophils, NF-κB activation, iNOS, cytokines levels (TNF-α and IL-1β), neurotrophin expression were markedly reduced by MK801 treatment. Moreover, in a separate set of experiments, we have demonstrated that MK801 treatment significantly improved the recovery of locomotory function.
conclusionsBlockade of NMDA by MK801 lends support to the potential importance of NMDA antagonists as therapeutic agents in the treatment of acute spinal cord injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.