ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
New doxycycline-inducible transgenic lines in Xenopus.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Tbx5 driveseLife · 2021Article
- Xenopus as a platform for discovery of genes relevant to human disease.Current topics in developmental biology · 2021Review
- Axial Skeletal Malformations in Genetically ModifiedComparative medicine · 2020Article
- Modeling congenital kidney diseases inDisease models & mechanisms · 2019Review
- Regulation of neural crest development by the formin family protein Daam1.Genesis (New York, N.Y. : 2000) · 2018Article
- Is adult cardiac regeneration absent inCell & bioscience · 2018Article
- Direct Regulation of Histidine Ammonia-Lyase 2 Gene by Thyroid Hormone in the Developing Adult Intestinal Stem Cells.Endocrinology · 2017Article
- Thyroid Hormone-Induced Activation of Notch Signaling is Required for Adult Intestinal Stem Cell Development During Xenopus Laevis Metamorphosis.Stem cells (Dayton, Ohio) · 2017Article
- Imaging MyelinationBrain plasticity (Amsterdam, Netherlands) · 2016Review
- Functional joint regeneration is achieved using reintegration mechanism in Xenopus laevis.Regeneration (Oxford, England) · 2016Article
- Article
- An inducible expression system to measure rhodopsin transport in transgenic Xenopus rod outer segments.PloS one · 2013Article
- Inducible genetic system for the axolotl.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Development of Xenopus resource centers: the National Xenopus Resource and the European Xenopus Resource Center.Genesis (New York, N.Y. : 2000) · 2012Review
- Thyroid hormone-induced sonic hedgehog signal up-regulates its own pathway in a paracrine manner in the Xenopus laevis intestine during metamorphosis.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
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3 authors.
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Abstract
We have characterized two new transgenic Xenopus lines enabling transgene expression using the Tet-On inducible system. An inducer line expresses the doxycycline- (Dox-) activated transcription factor rtTA under control of the ubiquitous promoter CMV. A responder line enables Dox-inducible expression of a dominant positive thyroid hormone receptor via a tetracycline responsive transgenic promoter (TRE). Dox-induced expression of transgenic GFP mRNA was detectable after 3 hr and increased up to 10- to 50-fold by 2 days depending on dose of Dox. Induced GFP mRNA expression returned to uninduced levels within 3 days upon Dox removal. Treatment of rtTA inducer and TRE responder double transgenic animals with Dox caused acceleration of metamorphic changes in thyroid hormone-response gene expression and morphology. These transgenic lines will be made available through the new Xenopus Stock Center and will serve as valuable tools for genetic analysis of development and metamorphosis.
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