SynthesisThe Cochrane database of systematic reviews2011
Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria.
Synthesis in The Cochrane database of systematic reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Osmotic therapies added to antibiotics for acute bacterial meningitis.The Cochrane database of systematic reviews · 2018Pooled it
- Osmotic therapies added to antibiotics for acute bacterial meningitis.The Cochrane database of systematic reviews · 2013Pooled it
- Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Trial
- Hypothyroidism confers tolerance to cerebral malaria.Science advances · 2022Article
- Cerebral malaria--clinical manifestations and pathogenesis.Metabolic brain disease · 2016Review
- The evidence for a role of vasospasm in the pathogenesis of cerebral malaria.Malaria journal · 2015Review
- Contrasting pediatric and adult cerebral malaria: the role of the endothelial barrier.Virulence · 2013Review
- Cerebral Malaria Treated with Artemisinin in the Intensive Care Unit: A Case Report.Iranian journal of parasitologyArticle
Corrections and comments
- Update of
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCerebral oedema occurs with cerebral malaria, and some clinicians think osmotic diuretics, such as mannitol or urea, may improve outcomes.
objectivesTo compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria. SEARCH STRATEGY: We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010), EMBASE (1974 to November 2010), LILACS (1982 to November 2010), and the reference lists of articles. We contacted relevant organizations and researchers. SELECTION CRITERIA: Randomized or quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. Primary outcomes were death, life-threatenining sequelae and major neurological sequelae at six months. DATA COLLECTION AND ANALYSIS: Two authors applied the inclusion criteria, assessed risk of bias, and extracted data independently. MAIN
resultsOne trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed. No difference in mortality, time to regain consciousness, or neurological sequelae were detected. AUTHORS'
conclusionsThere are insufficient data to know what the effects of osmotic diuretics are in children with cerebral malaria. Larger, multicentre trials are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.