ArticleJournal of clinical immunology2011
Thymic and bone marrow output in patients with common variable immunodeficiency.
Article in Journal of clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Utility of simultaneous quantification of TREC/KREC in patients with common variable immunodeficiency phenotype: an observational study from North India.Immunologic research · 2025Observational
- Can T-cell and B-cell excision circles predict development of inhibitors in pediatric hemophilia A?Pediatric research · 2023Article
- Age-Related Lymphocyte Output During Disease-Modifying Therapies for Multiple Sclerosis.Drugs & aging · 2020Observational
- Lymphocyte Subgroups and KREC Numbers in Common Variable Immunodeficiency: A Single Center Study.Journal of clinical immunology · 2020Article
- Differentiation of Common Variable Immunodeficiency From IgG Deficiency.The journal of allergy and clinical immunology. In practice · 2019Article
- The ESC: The Dangerous By-Product of V(D)J Recombination.Frontiers in immunology · 2019Review
- Thymopoiesis in Pre- and Post-Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2018Article
- Influence of immunologic status on age prediction using signal joint T cell receptor excision circles.International journal of legal medicine · 2017Article
- Clonal and constricted T cell repertoire in Common Variable Immune Deficiency.Clinical immunology (Orlando, Fla.) · 2017Article
- Detection of newly produced T and B lymphocytes by digital PCR in blood stored dry on nylon flocked swabs.Journal of translational medicine · 2017Article
- Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- T-cell abnormalities in common variable immunodeficiency: the hidden defect.Journal of clinical pathology · 2016Review
- Insight into normal thymic activity by assessment of peripheral blood samples.Immunologic research · 2015Article
- Simultaneous quantification of T-cell receptor excision circles (TRECs) and K-deleting recombination excision circles (KRECs) by real-time PCR.Journal of visualized experiments : JoVE · 2014Article
- Defective functions of polymorphonuclear neutrophils in patients with common variable immunodeficiency.Immunologic research · 2014Article
- Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors.PloS one · 2014Article
- Utilization of TREC and KREC quantification for the monitoring of early T- and B-cell neogenesis in adult patients after allogeneic hematopoietic stem cell transplantation.Journal of translational medicine · 2013Article
- Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies.Journal of translational medicine · 2013Review
- T-cell Receptor and K-deleting Recombination Excision Circles in Newborn Screening of T- and B-cell Defects: Review of the Literature and Future Challenges.Journal of public health research · 2013Review
- Long-Term Non-Progression and Broad HIV-1-Specific Proliferative T-Cell Responses.Frontiers in immunology · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study aims to obtain more information about the immune deficit of common variable immunodeficiency (CVID) patients. MATERIALS AND
methodsA new real-time PCR assay was used to quantify T and B lymphocyte mobilization from the production and maturation sites through the detection of T cell receptor excision circles (TRECs) and kappa-deleting recombination circles (KRECs) and to allow the estimation of the average number of B cell divisions. T and B lymphocyte subsets were analyzed by flow cytometry.
resultsThe number of TREC(+) lymphocytes, which depends on age and gender, was significantly reduced in CVID patients. Similarly, KREC concentration was lower than in controls. Classification of patients according to the percentage of memory switched B cells showed that patients belonging to MB2 group and therefore with conserved B cell maturation have the lowest new B cell output but increased average peripheral divisions, leading to the highest B cell number.
conclusionsTREC and KREC quantification can be helpful for a more complete and informative understanding of a heterogeneous disease such as CVID.
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Registered trials
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