ArticlePloS one2011
Increase in female liver cancer in the Gambia, West Africa: evidence from 19 years of population-based cancer registration (1988-2006).
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2020Pooled it
- An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- 20-years of population-based cancer registration in hepatitis B and liver cancer prevention in the Gambia, West Africa.PloS one · 2013Trial
- Primary liver cancer at tertiary healthcare facility in Guinea: a cross-sectional study.BMC gastroenterology · 2026Article
- Prevalence of hepatitis B infection in the Gambian population: A narrative review of recent developments.Preventive medicine reports · 2023Review
- Decrease in liver cancer incidence rates in Bamako, Mali over 28 years of population-based cancer registration (1987-2015).World journal of hepatology · 2022Article
- Article
- Prognostic Values and Clinical Significance of S100 Family Member's Individualized mRNA Expression in Pancreatic Adenocarcinoma.Frontiers in genetics · 2021Article
- Article
- Cancers Attributable to Alcohol Consumption in Nigeria: 2012-2014.Frontiers in oncology · 2017Article
- Profile of cancer patients' seen at Korle Bu teaching hospital in Ghana (a cancer registry review).BMC research notes · 2014Review
- A Practical Approach Based on Analytic Deformable Algorithm for Scenic Image Registration.PloS one · 2013Article
- TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia.Carcinogenesis · 2012Article
- Article
- Registration accuracy and quality of real-life images.PloS one · 2012Article
- CDC23 regulates cancer cell phenotype and is overexpressed in papillary thyroid cancer.Endocrine-related cancer · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundHepatocellular carcinoma (HCC) is a common malignancy worldwide with a high burden in West Africa. Male to female ratios show consistent bias toward males, the biological bases and variations of which are not well understood. We have used data from the Gambian National Cancer Registry to compare trends in incidence of HCC in both genders. METHODS AND
findingsTwo periods were compared, 1988-1997 (early) and 1998-2006 (recent). In addition, the regression program joinpoint was used to assess trends over 19 years. Differences with self-reported ethnicity were assessed for the recent period using population data from 2003 census. Male to female ratio showed a significant decrease between the two periods from 3.28∶1 (95% CI, [2.93-3.65]) to 2.2∶1 (95% CI, [1.99-2.43]). Although rates in males were relatively stable (38.36 and 32.84 for, respectively, early and recent periods), they increased from 11.71 to 14.9 in females with a significant Annual Percentage Change of 3.01 [0.3-5.8] over 19 years and an increase in number of cases of 80.28% (compared to 26% in males). Significant variations in HCC risk, but not in gender ratio were observed in relation with ethnicity.
conclusionThis analysis of the only national, population-based cancer registry in West Africa shows a significant increase in HCC in females over recent years. This increase may be the consequence of major changes in lifestyle or viral risk factors, in particular obesity and hepatitis C, which have both been documented to increase in West Africa during recent years.
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Registered trials
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