ReviewVascular health and risk management2011
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.
Review in Vascular health and risk management, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Therapeutic potential of L-carnitine in coronary artery disease: a systematic review.Inflammopharmacology · 2026Pooled it
- L-carnitine for cognitive enhancement in people without cognitive impairment.The Cochrane database of systematic reviews · 2017Pooled it
- Effects of L-carnitine supplementation on oxidative stress and antioxidant enzymes activities in patients with coronary artery disease: a randomized, placebo-controlled trial.Nutrition journal · 2014Trial
- Mechanistic attenuation by L-carnitine of trastuzumab-induced downregulation of adenosine monophosphate -activated protein kinase signal in cardiac H9c2 cells.BMC pharmacology & toxicology · 2026Article
- Metabolomic Insights on Obesity and Diabetes from Feeding Diets Varying in Carbohydrate-Fat Ratios in Zucker Diabetic Fatty (ZDF) and Lean Zucker (ZInternational journal of molecular sciences · 2026Article
- Blood pressure improvement after resection of non-functioning adrenal adenomas: influencing factors and serum metabolic features.Frontiers in molecular biosciences · 2025Article
- Revisiting the Role of Carnitine in Heart Disease Through the Lens of the Gut Microbiota.Nutrients · 2024Review
- The therapeutic landscape of citrin deficiency.Journal of inherited metabolic disease · 2024Review
- A Prospective, Case-Control Study of Serum Metabolomics in Neonates with Late-Onset Sepsis and Necrotizing Enterocolitis.Journal of clinical medicine · 2022Article
- Carnitine deficiency among hospitalized pediatric patients: A retrospective study of critically ill patients receiving extracorporeal membrane oxygenation therapy.JPEN. Journal of parenteral and enteral nutrition · 2021Article
- Offspring sex affects the susceptibility to maternal smoking-induced lung inflammation and the effect of maternal antioxidant supplementation in mice.Journal of inflammation (London, England) · 2020Article
- Cardiac differentiation of bone-marrow-resident c-kitJournal of biosciences · 2020Article
- Possible role of l-carnitine in improvement of metabolic and hepatic changes in hyperuricemic and hyperuricemic-Fructose-supplemented rats.Physiological reports · 2019Article
- L-carnitine reduces acute lung injury in experimental biliary obstruction.Saudi medical journal · 2015Article
- Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.Nature medicine · 2013Article
- Acetyl-l-carnitine and oxfenicine on cardiac pumping mechanics in streptozotocin-induced diabetes in male Wistar rats.PloS one · 2013Article
- Complementary and alternative medicine and cardiovascular disease: an evidence-based review.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases.World journal of gastroenterology · 2012Article
- Lipid-induced mitochondrial stress and insulin action in muscle.Cell metabolism · 2012Article
- Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency.European journal of nutrition · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have been extensively evaluated in animals and humans during the last 20 years. For instance, many clinical trials have suggested ALC and PLC as potential strategies in the management of peripheral arterial disease, heart and cerebral ischemia, and congestive heart failure. As a result, several experts have already aimed to revise the clinical evidence supporting the therapeutic use of ALC and PLC. On the basis of their conclusions, our aim was a critical review of the effectiveness of ALC and PLC in the treatment of cardiovascular diseases. Type 2 diabetes mellitus is an independent risk factor for the development of cardiovascular disease. Therefore we also describe recent studies that have addressed the emerging use of ALC and PLC amelioration of the insulin resistant state and its related morbidities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.