Evidence map›Paper›PMID 21490939›Full record

ReviewVascular health and risk management2011

Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification.

Carlos V Serrano, Marcelo Oranges, Vitor Brunaldi, Alexandre de M Soeiro, Tatiana Andreucci Torres, José Carlos Nicolau, José Antonio F Ramires

Open access · goldAbstract readReview
In one paragraph

Review in Vascular health and risk management, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Carlos V SerranoHeart Institute, Av Enéas de C Aguiar, 44 Building II, 2nd Floor, Room 12, São Paulo, SP 05403-000, Brazil. carlos.serrano@incor.usp.br
Marcelo Oranges
Vitor Brunaldi
Alexandre de M Soeiro
Tatiana Andreucci Torres
José Carlos Nicolau
José Antonio F Ramires
National Heart Institute · MYUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of calcification in coronary artery disease is gaining importance, both in research studies and in clinical application. Calcified plaque has long been considered to be the most important atherosclerotic plaque within the arterial tree and frequently presents a challenge for percutaneous intervention. Current investigations have shown that plaque calcification has a dynamic course that is closely related to the magnitude of vascular inflammation. Numerous inflammatory factors synthesized during the early stages of atherosclerosis induce the expression and activation of osteoblast-like cells localized in the arterial wall that produce calcium. There is no doubt that the role of these factors in calcification associated with coronary artery disease could be a crucial strategic point in prevention and treatment. A number of diagnostic imaging methods have been developed in recent years, but their performance needs to be improved. In this context, we undertook an update on coronary calcification, focusing on physiopathology, clinical implications, and imaging techniques.

Indexed as

AnimalsCalcinosisCoronary Artery DiseaseCoronary VesselsHumansMuscle, Smooth, VascularOsteogenesisPhenotypePrognosisSignal Transductionatherosclerotic plaquesvascular calcificationvascular smooth muscle cells

Identifiers

PMID21490939
PMCPMC3072737
OpenAlexW1820690989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.